CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 20 > Issue 5 > Article
Open Access
23 December 2014 Linear-array-based photoacoustic imaging of human microcirculation with a range of high frequency transducer probes
Haroon Zafar, Aedán Breathnach, Hrebesh M. Subhash, Martin J. Leahy
Author Affiliations +
Journal of Biomedical Optics, Vol. 20, Issue 5, 051021 (December 2014). https://doi.org/10.1117/1.JBO.20.5.051021
Abstract
Photoacoustic imaging (PAI) with a linear-array-based probe can provide a convenient means of imaging the human microcirculation within its native structural context and adds functional information. PAI using a multielement linear transducer array combined with multichannel collecting system was used for in vivo volumetric imaging of the blood microcirculation, the total concentration of hemoglobin (HbT), and the hemoglobin oxygen saturation (sO2) within human tissue. Three-dimensional (3-D) PA and ultrasound (US) volumetric scans were acquired from the forearm skin by linearly translating the transducer with a stepper motor over a region of interest, while capturing two-dimensional images using 15, 21, and 40 MHz frequency transducer probes. For the microvasculature imaging, PA images were acquired at 800- and 1064-nm wavelengths. For the HbT and sO2 estimates, PA images were collected at 750- and 850-nm wavelengths. 3-D microcirculation, HbT, and sO2 maps of the forearm skin were obtained from normal subjects. The linear-array-based PAI has been found promising in terms of resolution, imaging depth, and imaging speed for in vivo microcirculation imaging within human skin. We believe that a reflection type probe, similar to existing clinical US probes, is most likely to succeed in real clinical applications. Its advantages include ease of use, speed, and familiarity for radiographers and clinicians.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2015/$25.00 © 2015 SPIE
Citation Download Citation
Haroon Zafar, Aedán Breathnach, Hrebesh M. Subhash, and Martin J. Leahy "Linear-array-based photoacoustic imaging of human microcirculation with a range of high frequency transducer probes," Journal of Biomedical Optics 20(5), 051021 (23 December 2014). https://doi.org/10.1117/1.JBO.20.5.051021
Published: 23 December 2014
JOURNAL ARTICLE
 7 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 33 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Transducers
Skin
In vivo imaging
3D image processing
Photoacoustic imaging
Imaging systems
Image resolution
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top