Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography–x-ray computed tomography

Xiaopeng Ma; Jaya Prakash; Francesca Ruscitti; Sarah Glasl; Fabio Franco Stellari; Gino Villetti; Vasilis Ntziachristos

doi:10.1117/1.JBO.21.1.015009

21 January 2016 Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography–x-ray computed tomography

Xiaopeng Ma, Jaya Prakash, Francesca Ruscitti, Sarah Glasl, Fabio Franco Stellari, Gino Villetti, Vasilis Ntziachristos

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Journal of Biomedical Optics, Vol. 21, Issue 1, 015009 (January 2016). https://doi.org/10.1117/1.JBO.21.1.015009

Abstract

Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and Aspergillus species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with ex vivo cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.

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Xiaopeng Ma, Jaya Prakash, Francesca Ruscitti, Sarah Glasl, Fabio Franco Stellari, Gino Villetti, and Vasilis Ntziachristos "Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography–x-ray computed tomography," Journal of Biomedical Optics 21(1), 015009 (21 January 2016). https://doi.org/10.1117/1.JBO.21.1.015009

Published: 21 January 2016

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