Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

Wei Wei; Jingjiang Xu; Utku Baran; Shaozhen Song; Wan Qin; Xiaoli Qi; Ruikang K. Wang

doi:10.1117/1.JBO.21.3.036005

11 March 2016 Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

Wei Wei, Jingjiang Xu, Utku Baran, Shaozhen Song, Wan Qin, Xiaoli Qi, Ruikang K. Wang

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Journal of Biomedical Optics, Vol. 21, Issue 3, 036005 (March 2016). https://doi.org/10.1117/1.JBO.21.3.036005

Abstract

We demonstrate in vivo volumetric optical microangiography at ∼200 volumes/s by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo. For the first time, imaging speed, sensitivity, and temporal resolution become possible for a direct four-dimensional observation of microcirculations within live body parts.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Wei Wei, Jingjiang Xu, Utku Baran, Shaozhen Song, Wan Qin, Xiaoli Qi, and Ruikang K. Wang "Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow," Journal of Biomedical Optics 21(3), 036005 (11 March 2016). https://doi.org/10.1117/1.JBO.21.3.036005

Published: 11 March 2016

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