In vivo photoacoustic tomography of myoglobin oxygen saturation

Li Lin; Junjie Yao; Lei Li; Lihong V. Wang

doi:10.1117/1.JBO.21.6.061002

17 December 2015 In vivo photoacoustic tomography of myoglobin oxygen saturation

Li Lin, Junjie Yao, Lei Li, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 21, Issue 6, 061002 (December 2015). https://doi.org/10.1117/1.JBO.21.6.061002

Abstract

Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O₂) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO₂-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO₂-Mb change in the backbone muscle invivo.

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Li Lin, Junjie Yao, Lei Li, and Lihong V. Wang "In vivo photoacoustic tomography of myoglobin oxygen saturation," Journal of Biomedical Optics 21(6), 061002 (17 December 2015). https://doi.org/10.1117/1.JBO.21.6.061002

Published: 17 December 2015

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