Skin optical clearing potential of disaccharides

Wei Feng; Rui Shi; Ning Ma; Daria K. Tuchina; Valery V. Tuchin; Dan Zhu

doi:10.1117/1.JBO.21.8.081207

25 April 2016 Skin optical clearing potential of disaccharides

Wei Feng, Rui Shi, Ning Ma, Daria K. Tuchina, Valery V. Tuchin, Dan Zhu

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Journal of Biomedical Optics, Vol. 21, Issue 8, 081207 (April 2016). https://doi.org/10.1117/1.JBO.21.8.081207

Abstract

Skin optical clearing can significantly enhance the ability of biomedical optical imaging. Some alcohols and sugars have been selected to be optical clearing agents (OCAs). In this work, we paid attention to the optical clearing potential of disaccharides. Sucrose and maltose were chosen as typical disaccharides to compare with fructose, an excellent monosaccharide-OCA, by using molecular dynamics simulation and an ex vivo experiment. The experimental results indicated that the optical clearing efficacy of skin increases linearly with the concentration for each OCA. Both the theoretical predication and experimental results revealed that the two disaccharides exerted a better optical clearing potential than fructose at the same concentration, and sucrose is optimal. Since maltose has an extremely low saturation concentration, the other two OCAs with saturation concentrations were treated topically on rat skin in vivo, and optical coherence tomography imaging was applied to monitor the optical clearing process. The results demonstrated that sucrose could cause a more significant increase in imaging depth and signal intensity than fructose.

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Wei Feng, Rui Shi, Ning Ma, Daria K. Tuchina, Valery V. Tuchin, and Dan Zhu "Skin optical clearing potential of disaccharides," Journal of Biomedical Optics 21(8), 081207 (25 April 2016). https://doi.org/10.1117/1.JBO.21.8.081207

Published: 25 April 2016

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