Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate

Raju Poddar; Justin V. Migacz; Daniel M. Schwartz; John S. Werner; Iwona Gorczynska

doi:10.1117/1.JBO.22.10.106018

31 October 2017 Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate

Raju Poddar, Justin V. Migacz, Daniel M. Schwartz, John S. Werner, Iwona Gorczynska

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Journal of Biomedical Optics, Vol. 22, Issue 10, 106018 (October 2017). https://doi.org/10.1117/1.JBO.22.10.106018

Abstract

We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks. The OCTA imaging was performed with a field of view of 16 deg ( 5 mm×5 mm) and 30 deg ( 9 mm×9 mm). Data were presented in en face projections generated from single volumes and in en face projection mosaics generated from up to 4 datasets. OCTA imaging at 1.7 MHz A-scan rate was compared with results obtained from a commercial OCTA instrument and with conventional ophthalmic diagnostic methods: fundus photography, fluorescein, and indocyanine green angiography. Comparison of images obtained from all methods is demonstrated using the same eye of a healthy volunteer. For example, imaging of retinal pathology is presented in three cases of advanced age-related macular degeneration.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Raju Poddar, Justin V. Migacz, Daniel M. Schwartz, John S. Werner, and Iwona Gorczynska "Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate," Journal of Biomedical Optics 22(10), 106018 (31 October 2017). https://doi.org/10.1117/1.JBO.22.10.106018

Received: 25 May 2017; Accepted: 4 October 2017; Published: 31 October 2017

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