Handheld optical-resolution photoacoustic microscopy

Li Lin; Pengfei Zhang; Song Xu; Junhui Shi; Lei Li; Junjie Yao; Lidai Wang; Jun Zou; Lihong V. Wang

doi:10.1117/1.JBO.22.4.041002

24 October 2016 Handheld optical-resolution photoacoustic microscopy

Li Lin, Pengfei Zhang, Song Xu, Junhui Shi, Lei Li, Junjie Yao, Lidai Wang, Jun Zou, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 4, 041002 (October 2016). https://doi.org/10.1117/1.JBO.22.4.041002

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free in vivo imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer.

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Li Lin, Pengfei Zhang, Song Xu, Junhui Shi, Lei Li, Junjie Yao, Lidai Wang, Jun Zou, and Lihong V. Wang "Handheld optical-resolution photoacoustic microscopy," Journal of Biomedical Optics 22(4), 041002 (24 October 2016). https://doi.org/10.1117/1.JBO.22.4.041002

Published: 24 October 2016

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