Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Yuan Qu; Chiye Li; Junhui Shi; Ruimin Chen; Song Xu; Hasan Rafsanjani; Konstantin Maslov; Hannah Krigman; Laura Garvey; Peng Hu; Peinan Zhao; Karen Meyers; Emily Diveley; Stephanie Pizzella; Lisa Muench; Nina Punyamurthy; Naomi Goldstein; Oji Onwumere; Mariana Alisio; Kaytelyn Meyenburg; Jennifer Maynard; Kristi Helm; Janessia Slaughter; Sabrina Barber; Tracy Burger; Christine Kramer; Jessica Chubiz; Monica Anderson; Ronald McCarthy; Sarah K. England; George A. Macones; Qifa Zhou; K. Kirk Shung; Jun Zou; Molly J. Stout; Methodius Tuuli; Lihong V. Wang

doi:10.1117/1.JBO.23.12.121617

5 December 2018 Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 12, 121617 (December 2018). https://doi.org/10.1117/1.JBO.23.12.121617

Abstract

Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250-Hz B-scan rate over a 3-mm scanning range. Using this modality, we not only illustrated the morphological differences of vasculatures among the human ectocervix, uterine body, and sublingual mucosa but also showed the longitudinal and cross-sectional differences of cervical vasculatures in pregnant women. This technology is promising for screening the visceral pathological changes associated with angiogenesis.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zou, Molly J. Stout, Methodius Tuuli, and Lihong V. Wang "Transvaginal fast-scanning optical-resolution photoacoustic endoscopy," Journal of Biomedical Optics 23(12), 121617 (5 December 2018). https://doi.org/10.1117/1.JBO.23.12.121617

Received: 15 August 2018; Accepted: 5 November 2018; Published: 5 December 2018

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