Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

Jianbo Tang; Sefik Evren Erdener; Smrithi Sunil; David A. Boas

doi:10.1117/1.JBO.24.3.036005

13 March 2019 Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

Jianbo Tang, Sefik Evren Erdener, Smrithi Sunil, David A. Boas

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Journal of Biomedical Optics, Vol. 24, Issue 3, 036005 (March 2019). https://doi.org/10.1117/1.JBO.24.3.036005

Abstract

Optical coherence tomography angiography (OCTA) has been widely used for en face visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the “tail” artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (g₁-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating arterioles from venules in the 3-D image. g₁ ( τ ) is calculated from repeated optical coherence tomography (OCT) acquisitions for each spatial location. The decay amplitude of g₁ ( τ ) is retrieved to represent the dynamics for each voxel. To account for the small g₁ ( τ ) decay in capillaries where red blood cells are flowing slowly and discontinuously, Intralipid is injected to enhance the OCT signal. We demonstrate that the proposed technique realizes 3-D OCTA with negligible tail projections and the penetrating arteries are readily identified. In addition, compared to regular OCTA, the proposed g₁-OCTA largely increased the depth-of-field. This technique provides a more accurate rendering of the vascular 3-D anatomy and has the potential for more quantitative characterization of vascular networks.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jianbo Tang, Sefik Evren Erdener, Smrithi Sunil, and David A. Boas "Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography," Journal of Biomedical Optics 24(3), 036005 (13 March 2019). https://doi.org/10.1117/1.JBO.24.3.036005

Received: 7 November 2018; Accepted: 6 February 2019; Published: 13 March 2019

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