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24 December 2022 Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy
Nisha Maheshwari, Alessandro Marone, Mirella Altoé, Stephen H. K. Kim, Danielle R. Bajakian, Andreas H. Hielscher
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Journal of Biomedical Optics, Vol. 27, Issue 12, 125002 (December 2022). https://doi.org/10.1117/1.JBO.27.12.125002
Abstract

Significance

Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention.

Aim

We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention.

Approach

The DVOS used near-infrared light (670 < λ < 850 nm) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible.

Results

The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size (N = 9) and patients with ulcers that did not (N = 5) 3 to 4 weeks after intervention (p value < 0.001). Data correlated strongly (89% sensitivity, 100% specificity, and AUC = 0.96) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing.

Conclusions

This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Nisha Maheshwari, Alessandro Marone, Mirella Altoé, Stephen H. K. Kim, Danielle R. Bajakian, and Andreas H. Hielscher "Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy," Journal of Biomedical Optics 27(12), 125002 (24 December 2022). https://doi.org/10.1117/1.JBO.27.12.125002
Received: 13 October 2022; Accepted: 12 December 2022; Published: 24 December 2022
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KEYWORDS
Wound healing
Arteries
Data acquisition
Diseases and disorders
Blood
Lab on a chip
Vascular diseases
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