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18 April 2024 Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels
Eugene Yu-Chuan Kang, Chia-Rui Shen, Xin-Cheng Huang, Chun-Ya Kang, Tzu-Yi Lin, Wei-Hsin Hong, Lan-Yan Yang, Wei-Chi Wu, Yih-Shiou Hwang
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Journal of Biomedical Optics, Vol. 29, Issue 4, 047001 (April 2024). https://doi.org/10.1117/1.JBO.29.4.047001
Abstract

Significance

Monitoring blood glucose levels is crucial for individuals with diabetes. Noninvasive methods for measuring serum glucose levels have been explored to aid in blood glucose control for diabetes management.

Aim

We introduced a noncontact optical glucometer (NCGM) for measuring glucose levels in the aqueous humor of the human eye. We also investigated the correlation between glucose levels in the NCGM and the aqueous humor, blood samples, and self-monitoring blood glucose devices.

Approach

The optical system used in this study measured both the near-infrared absorption and polarized rotatory distribution of glucose molecules in the human aqueous humor. This prospective study’s outcomes were eye aqueous glucose level, preoperative blood glucose level, intraoperative blood glucose level, and NCGM reading of patients in a single center in Taiwan.

Results

The NCGM’s measurements showed a strong correlation with blood glucose levels (intra-class correlation [ICC]: 0.95 to 0.98) and aqueous humor glucose levels (ICC: 0.76), indicating its ability to noninvasively measure blood glucose levels in human subjects.

Conclusions

This NCGM may offer a convenient, pain-free, and rapid tool for measuring blood glucose levels in diabetic patients. The device could represent a significant advancement in noncontact hybrid optical glucose measurement systems.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Eugene Yu-Chuan Kang, Chia-Rui Shen, Xin-Cheng Huang, Chun-Ya Kang, Tzu-Yi Lin, Wei-Hsin Hong, Lan-Yan Yang, Wei-Chi Wu, and Yih-Shiou Hwang "Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels," Journal of Biomedical Optics 29(4), 047001 (18 April 2024). https://doi.org/10.1117/1.JBO.29.4.047001
Received: 28 December 2023; Accepted: 26 March 2024; Published: 18 April 2024
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KEYWORDS
Glucose
Blood
Eye
Optical testing
Biological samples
Optical components
Molecules
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