In vitro and in vivo study of dye diffusion into the human skin and hair follicles

Elina A. Genina; Alexey N. Bashkatov; Yury P. Sinichkin; Vyacheslav I. Kochubey; Nina A. Lakodina; Gregory B. Altshuler; Valery V. Tuchin

doi:10.1117/1.1486247

1 July 2002 In vitro and in vivo study of dye diffusion into the human skin and hair follicles

Elina A. Genina, Alexey N. Bashkatov, Yury P. Sinichkin, Vyacheslav I. Kochubey, Nina A. Lakodina, Gregory B. Altshuler, Valery V. Tuchin

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Journal of Biomedical Optics, Vol. 7, Issue 3, (July 2002). https://doi.org/10.1117/1.1486247

Abstract

We present experimental results on the in vitro and in vivo study of dye diffusion into human skin and hair follicles. We have studied some commercially available dyes for potential using in the laser selective thermolysis. The degree and the depth of hair follicle dyeing inside the skin were determined. For hairs in different stages the sebaceous gland was stated as a reservoir for a dye administration. It was found that the penetration depth of dyes is about 1.2 mm from the skin surface. We have developed the biocompatible Indocyanine Green lotions and the method for in vivo dyeing and dye in depth monitoring. Shift on 16–21 nm of absorption peak of Indocyanine Green to the longer wavelengths due to Indocyanine Green binding with cell proteins in the human skin was found.

©(2002) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Elina A. Genina, Alexey N. Bashkatov, Yury P. Sinichkin, Vyacheslav I. Kochubey, Nina A. Lakodina, Gregory B. Altshuler, and Valery V. Tuchin "In vitro and in vivo study of dye diffusion into the human skin and hair follicles," Journal of Biomedical Optics 7(3), (1 July 2002). https://doi.org/10.1117/1.1486247

Published: 1 July 2002

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