Mr. Alexander P. Khorovodov Profile

Alexander P. Khorovodov

at Saratov State Univ

SPIE Involvement:

Author

Publications (17)

Proceedings Article | 9 April 2020 Paper

Conjugation of Zn (II) phthalocyanine with polymeric brushes for improved photodiagnostics and photodynamic therapy of gastric tumours

E. Borisova, Ts. Genova, A. Yakimansky, V. Mantareva, I. Angelov, A. Gisbrecht, Al. Khorovodov, I. Agranovich, M. Klimova, O. Semyachkina-Glushkovskaya

Proceedings Volume 11457, 114570R (2020) https://doi.org/10.1117/12.2559938

KEYWORDS: Polymers, Photodynamic therapy, Luminescence, Molecules, In vivo imaging, Cancer, Fluorescence spectroscopy, Tissues

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The target-specific drug release which is depending on the pH of the medium appears precious approach for increasing of drug selectivity and further efficacy in photodynamic diagnosis (PDD) and therapy (PDT) of cancer. A strongly hydrophobic Zn (II) phthalocyanine (ZnPc) along with its liposomal formulates belongs to the clinically approved phthalocyanines for cancer photodiagnosis PDD and PDT. Nevertheless closed to the ideal photo-physicochemical properties the planar molecular structure of ZnPc easily forms aggregates which finally limit the phototoxic effect. Different strategies are on hand, all aiming to minimize the formation of photo-inactive associates. At present time, the polymeric carrier systems are still under development as carrier systems for biomedical applications. The present work evaluated the efficiency of two recently proposed graft - copolymers namely polyimide (PI)-graft-polymethacrylic acid (PAT2 and PAT3) as vehicles of hydrophobic ZnPc. The potential of the proposed polymeric brushes with great number of carboxylic groups, for conformational changes in different pH media, can be used for ZnPc release as studied by fluorescence spectroscopy. Complexes developed were investigated in vivo on rat model system of gastric carcinoma lesions for photodiagnosis and photodynamic treatment of neoplasia and compared with the application of ZnPcs solely. The contrast achieved of the fluorescence detection using polymer brushes - phthalocyanine conjugate is about twice higher that standard applied photosensitizer using same protocol and doses of application. The photodynamic treatment efficacy was also significantly improved allowing to receive full response using doses of 0,5-1 mg/kg of the conjugates. |To obtain same efficiency for the ZnPc PDT in the gastric lesions treated drug doses of 1,5-2 mg/kg had to be applied. Initially detected fluorescence signal and photo-bleaching dynamics were used for the monitoring of the processes of accumulation and photodynamic treatment processes.

Proceedings Article | 9 April 2020 Paper

Detection of early gastric cancer with wavelets

Alexander Khorovodov, Ilana Agranovich, Nikita Navolokin, Olga Pavlova, Alexey Pavlov, Ekaterina Borisova, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11459, 114590J (2020) https://doi.org/10.1117/12.2559693

KEYWORDS: Stomach, Cancer, Blood circulation, Wavelets, Diagnostics, Animal model studies, Tumors, Discrete wavelet transforms, Statistical analysis, Tumor growth modeling

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Proceedings Article | 2 April 2020 Presentation + Paper

5-ALA/PpIX photodiagnosis of stress-induced gastrointestinal metastatic tumours in laboratorial animals

Ekaterina Borisova, Matvey Kanevskiy, Svetlana Konnova, Alexander Khorovodov, Ilana Agranovich, Tsanislava Genova, Latchezar Avramov, Nikita Navolokin, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11363, 113630U (2020) https://doi.org/10.1117/12.2555992

KEYWORDS: Stomach, Tissues, Luminescence, Liver, Diagnostics, Cancer, Animal model studies, Spectroscopy, Biological research

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Proceedings Article | 6 March 2020 Presentation

Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer’s disease (Conference Presentation)

Oxana Semyachkina-Glushkovskaya, Ekaterina Zinchenko, Maria Klimova, Andrey Terskov, Arkady Abdurashitov, Alexander Dubrovsky, Inna Blokhina, Alexander Khorovodov, Ilana Agranovich, Nikita Navolokin, Alexander Shirokov, Elena Saranceva, Aysel Mamedova, Valery Tuchin, Juergen Kurths

Proceedings Volume 11241, 1124103 (2020) https://doi.org/10.1117/12.2541561

KEYWORDS: Brain, Alzheimer's disease, Lymphatic system, Optical coherence tomography, Confocal microscopy, Gold, Nanorods, Neck

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Proceedings Article | 22 July 2019 Paper

ALA/PpIX photodiagnosis of stress-induced gastrointestinal primary tumors and metastases in experimental animals

Ekaterina Borisova, Tsanislava Genova, Alexander Khorovodov, Ilana Agranovich, Matvey Kanevskiy, Svetlana Konnova, Ivan Angelov, Vanya Mantareva, Nikita Navolokin, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11079, 110790N (2019) https://doi.org/10.1117/12.2526847

KEYWORDS: Stomach, Luminescence, Liver, Tissues, Tumors, Spectroscopy, Cancer, Diagnostics, Fluorescent markers, In vivo imaging

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