In this preclinical study we demonstrated that treatment with repetitive magnetic stimulation (RMS) protects the epithelial layer in a rabbit model of exposure keratopathy, preventing loss of the epithelial cells and maintaining the function of the corneal barrier under extreme desiccation conditions. A single 15 minutes RMS treatment supported corneal barrier integrity under acute desiccation for 3 months. AS-OCT imaging and histopathology analysis demonstrated the safety of RMS treatment. Our study suggests that repetitive magnetic stimulation may present a novel treatment for protection of corneal epithelium in patients with DES, and may alleviate DES symptoms.
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