Dr. David H. Sliney Profile

Dr. David H. Sliney

Consulting Medical Physicist

SPIE Involvement:

Author | Editor

Proceedings Article | 20 June 2003 Paper

Sunglasses: their effectiveness

David Sliney

Proceedings Volume 4953, (2003) https://doi.org/10.1117/12.477907

KEYWORDS: Eye, Sun, Lenses, Retina, Ultraviolet radiation, Standards development, Injuries, Cornea, Visible radiation, Visualization

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Proceedings Article | 17 May 2001 Paper

Implications of using ED-50 and probit analysis in comparing retinal injury threshold data

David Sliney, John Mellerio, Karl Schulmeister

Proceedings Volume 4246, (2001) https://doi.org/10.1117/12.426711

KEYWORDS: Injuries, Safety, Eye, Biological research, Retina, Image quality, Laser damage threshold, Laser safety, Error analysis, Gas lasers

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Proceedings Article | 17 May 2001 Paper

Modeling of uncertainty associated with dose-response curves as applied for probabilistic risk assessment in laser safety

Karl Schulmeister, Gerald Sonneck, Herbert Hoedlmoser, Frank Rattay, John Mellerio, David Sliney

Proceedings Volume 4246, (2001) https://doi.org/10.1117/12.426713

KEYWORDS: Injuries, Absorption, Eye models, Laser damage threshold, Statistical analysis, Laser safety, Monte Carlo methods, Retina, Mathematical modeling, Pulsed laser operation

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In laser safety, dose-response curves describe the probability for ocular injury as a function of ocular energy, and are often used to quantify the risk for ocular injury given a certain level of exposure to laser radiation. In principal, a dose-response curve describes the biological variation of the individual thresholds in a population. In laser safety, a log-normal cumulative distribution is generally assumed for the dose-response curve, for instance when Probit analysis is performed. The lognormal distribution is defined by two parameters, the median, called ED50, and the slope. When animal experiments are performed to obtain dose-response curves for laser induced injury, experimental uncertainty such as focussing errors as well as variability within the group of experimental animals, such as inter-individual variability of absorption of the ocular media, can influence the shape of the dose-response curve. We present simulations of uncertainties and variabilities that show that the log-normal dose-response curve as obtained in a animal experiments can grossly overestimate the probability for ocular damage for small doses. It is argued that the intrinsic slope for an individual’s dose-response curve is rather steep, even for retinal injury, however, the dose-response curve for a group or population can be broader when there is inter-individual variability of parameters which influence the threshold. The quantitative results of the simulation of the grouping of individual dose-response curves can serve as basis to correct potentially biased dose-response curves as well as to characterize the uncertainty associated with the ED50 and the slope of the dose-response curve. A probabilistic risk analysis model, which accounts for these uncertainties by using Monte-Carlo simulation, was developed for retinal laser injuries from pulsed lasers with wavelengths from 200 nm to 20 µm, and the interpretation of the results are discussed on the basis of example calculations.

Proceedings Article | 3 March 2000 Paper

Overview of the range of mechanisms

David Sliney

Proceedings Volume 3902, (2000) https://doi.org/10.1117/12.379335

KEYWORDS: Injuries, Eye, Laser safety, Retina, Tissues, Standards development, Proteins, Laser damage threshold, Laser energy, Absorption

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Proceedings Article | 18 June 1999 Paper

Eye movements during fixation: implications to long-term viewing of small optical sources

James Ness, Harry Zwick, David Lund, Bruce Stuck, David Sliney

Proceedings Volume 3591, (1999) https://doi.org/10.1117/12.350595

KEYWORDS: Eye, Head, Retina, Laser safety, Standards development, Light emitting diodes, Visualization, Safety, Laser sources, Statistical analysis

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Proceedings Article | 14 June 1999 Paper

Appropriate radiometric quantities in laser dosimetry

David Sliney

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350031

KEYWORDS: Tissues, Scattering, Laser scattering, Skin, Natural surfaces, Tissue optics, Light scattering, Absorption, Rayleigh scattering, Laser therapeutics

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Proceedings Article | 2 May 1997 Paper

Potential ocular hazards from solar exposure during extravehicular activity

James Franks, David Sliney, Rodney Wood

Proceedings Volume 2974, (1997) https://doi.org/10.1117/12.275234

KEYWORDS: Sun, Injuries, Coating, Retina, Thermal effects, Eye, Solids, Medicine, Solar radiation, Earth's atmosphere

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Proceedings Article | 1 April 1996 Paper

Ocular injuries from laser accidents

David Sliney

Proceedings Volume 2674, (1996) https://doi.org/10.1117/12.237515

KEYWORDS: Injuries, Eye, Retina, Visualization, Q switched lasers, Carbon dioxide lasers, Nd:YAG lasers, Pulsed laser operation, Vitreous, Chromatic aberrations

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Proceedings Article | 10 August 1994 Paper

Infrared laser effects on the eye: implications for safety and medical applications

David Sliney

Proceedings Volume 2097, (1994) https://doi.org/10.1117/12.183180

KEYWORDS: Injuries, Electrophoretic light scattering, Safety, Cornea, Eye, Pulsed laser operation, Infrared radiation, Infrared lasers, Laser applications, Continuous wave operation

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Proceedings Article | 21 July 1994 Paper

Dosimetry for ultraviolet radiation exposure of the eye

David Sliney

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.180811

KEYWORDS: Eye, Ultraviolet radiation, Lamps, Cornea, Optical properties, Tissues

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Proceedings Article | 1 June 1991 Paper

Safety of medical excimer lasers with an emphasis on compressed gases

David Sliney, Terrance Clapham

Proceedings Volume 1423, (1991) https://doi.org/10.1117/12.43975

KEYWORDS: Excimer lasers, Safety, Fluorine, Laser systems engineering, Laser safety, Gases, Ozone, Sensors, Optical filters, Toxic gases

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Proceedings Article | 1 July 1990 Paper

Deriving exposure limits

David Sliney

Proceedings Volume 1207, (1990) https://doi.org/10.1117/12.17826

KEYWORDS: Laser safety, Standards development, Injuries, Eye, Ultraviolet radiation, Skin, Electroluminescence, Pulsed laser operation, Laser development, Radiation effects

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