Dr. Farouc A. Jaffer Profile

Dr. Farouc A. Jaffer

Principal Investigator at MGH Cardiovascular Research Ctr.

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Publications (14)

Proceedings Article | 13 March 2024 Poster

High-speed intravascular NIRF-IVUS imaging for the assessment of atherosclerosis in coronary-sized arteries

Philipp Rauschendorfer, Andrew Thrapp, Guillermo Tearney, Farouc Jaffer

Proceedings Volume 12819, 1281911 (2024) https://doi.org/10.1117/12.3009997

KEYWORDS: Arteries, Atherosclerosis, Intravascular ultrasound, In vivo imaging, Biological imaging, Target detection, Diseases and disorders, Visualization, Tissues, Structural imaging

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Proceedings Article | 13 March 2024 Presentation

IVUS or OCT in guiding revascularization: lessons learnt from the OPINION, ILUMIEN IV, and OCTIVUS studies

Farouc Jaffer

Proceedings Volume 12819, 128190E (2024) https://doi.org/10.1117/12.3024143

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SPIE Journal Paper | 5 April 2023 Open Access

Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire

Philipp Rauschendorfer, Georg Wissmeyer, Farouc A. Jaffer, Dimitris Gorpas, Vasilis Ntziachristos

JBO, Vol. 28, Issue 04, 046001, (April 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.4.046001

KEYWORDS: Blood, Signal attenuation, Capillaries, Tissues, Biological imaging, Attenuation correction, Intravascular ultrasound, Signal intensity, Arteries, Fluorescence intensity

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Proceedings Article | 17 March 2023 Presentation

3D printed freeform micro-optics for OCT coronary tissue imaging

Radhika Poduval, Fang Hou, Alejandro Ortega, Shoumik Lodh, Aditya Kumar, Ashwin Panikkar, Hinnerk Schulz-Hildebrandt, Lillian Wang, Joseph Gardecki, Farouc Jaffer, Guillermo Tearney

Proceedings Volume PC12356, PC123560D (2023) https://doi.org/10.1117/12.2651300

KEYWORDS: Tissues, Micro optics, 3D image processing, Optical coherence tomography, Tomography, Stereoscopy, Fiber optics, Visualization, Optics manufacturing, Optical components

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Proceedings Article | 7 March 2022 Presentation

Intravascular dual-modality optical coherence tomography and multichannel near-infrared fluorescence inflammation imaging with the cathepsin-activatable LUM015 imaging agent

Andrew Thrapp, Mohamad Kassab, Joseph Gardecki, Osman Ahsen, Yoichiro Kawamura, Adam Mauskapf, Graham Spicer, Evangelia Gavgiotaki, Aditya Kumar, Maya Modi, Ara Bablouzian, Paola Leon, Aidan Burbridge, Benjamin Childs, Farouc Jaffer, Guillermo Tearney

Proceedings Volume PC11936, PC1193602 (2022) https://doi.org/10.1117/12.2605295

KEYWORDS: Optical coherence tomography, Luminescence, Inflammation, Imaging systems, In vivo imaging, Visualization, Tomography, Target detection, Fluorescence spectroscopy, Coherence (optics)

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Proceedings Article | 8 March 2021 Presentation

Activated platelet detection using a glycoprotein IIb/IIIa targeted near infrared fluorescence imaging probe

Khanh Ha, Farouc Jaffer, Jason McCarthy, Xiaoxin Zheng, Chase Kessinger

Proceedings Volume 11660, 1166005 (2021) https://doi.org/10.1117/12.2577254

KEYWORDS: Near infrared, Target detection, Luminescence, In vivo imaging, Biological detection systems

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Proceedings Article | 5 March 2021 Presentation

Development of a clinical intravascular dual-modality optical coherence tomography and near-infrared autofluorescence/fluorescence imaging platform

Osman Ahsen, Zhonglie Piao, Aditya Kumar, Ara Bablouzian, Jia Liu, Mason Schellenberg, Paola Leon Alarcon, Andreas Wartak, Matthew Beatty, Benjamin Child, Adam Mauskapf, Mazen Albaghdadi, Ryutaro Ikegami, Sarah Giddings, Joseph Gardecki, Victoria Mathieu, Farouc Jaffer, Guillermo Tearney

Proceedings Volume 11621, 116210O (2021) https://doi.org/10.1117/12.2577841

KEYWORDS: Optical coherence tomography, Luminescence, Imaging systems, Tissues, Process control, Near infrared, Visualization, Standards development, Lens design, Control systems

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Proceedings Article | 1 August 2017 Paper

Intravascular optoacoustic catheter with extended sensitivity field

Dmitry Bozhko, Dimitris Gorpas, Farouc Jaffer, Vasilis Ntziachristos

Proceedings Volume 10415, 1041502 (2017) https://doi.org/10.1117/12.2286052

KEYWORDS: Intravascular ultrasound, Photoacoustic imaging, Photoacoustic tomography, Fluorescence tomography

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Proceedings Article | 17 February 2011 Paper

Double-cladding-fiber-based detection system for intravascular mapping of fluorescent molecular probes

R. Nika Razansky, Amir Rozental, Mathias Mueller, Nikolaos Deliolanis, Farouc Jaffer, Alexander Koch, Vasilis Ntziachristos

Proceedings Volume 7894, 78940K (2011) https://doi.org/10.1117/12.874653

KEYWORDS: Sensors, Cladding, Luminescence, GRIN lenses, In vivo imaging, Fluorescence spectroscopy, Waveguides, Inflammation, Single mode fibers, Polishing

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Early detection of high-risk coronary atherosclerosis remains an unmet clinical challenge. We have previously demonstrated a near-infrared fluorescence catheter system for two-dimensional intravascular detection of fluorescence molecular probes [1]. In this work we improve the system performance by introducing a novel high resolution sensor. The main challenge of the intravascular sensor is to provide a highly focused spot at an application relevant distance on one hand and a highly efficient collection of emitted light on the other. We suggest employing a double cladding optical fiber (DCF) in combination with focusing optics to provide a sensor with both highly focused excitation light and highly efficient fluorescent light collection. The excitation laser is coupled into the single mode core of DCF and guided through a focusing element and a right angle prism. The resulting side-fired beam exhibits a small spot diameter (50 μm) throughout a distance of up to 2 mm from the sensor. This is the distance of interest for intravascular coronary imaging application, determined by an average human coronary artery diameter. At the blood vessel wall, an activatable fluorescence molecular probe is excited in the diseased lesions. Next light of slightly shifted wavelength emits only in the places of the inflammations, associated with dangerous plaques [2]. The emitted light is collected by the cladding of the DCF, with a large collection angle (NA=0.4). The doublecladding acts as multimodal fiber and guides the collected light to the photo detection elements. The sensor automatically rotates and pulled-back, while each scanned point is mapped according to the amount of detected fluorescent emission. The resulting map of fluorescence activity helps to associate the atherosclerotic plaques with the inflammation process. The presented detection system is a valuable tool in the intravascular plaque detection and can help to differentiate the atherosclerotic plaques based on their biological activity, identify the ones that prone to rupture and therefore require more medical attention.

Proceedings Article | 10 February 2011 Paper

An algorithm to correct 2D near-infrared fluorescence signals using 3D intravascular ultrasound architectural information

Georgios Mallas, Dana Brooks, Amir Rosenthal, Claudio Vinegoni, Marcella Calfon, R. Nika Razansky, Farouc Jaffer, Vasilis Ntziachristos

Proceedings Volume 7892, 78920W (2011) https://doi.org/10.1117/12.875008

KEYWORDS: Luminescence, Intravascular ultrasound, Imaging systems, In vivo imaging, Algorithm development, Signal attenuation, Arteries, Blood, Biology, Near infrared

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SPIE Journal Paper | 1 February 2011 Open Access

Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall

Zeinab Hajjarian, Jingqun Xi, Guillermo Tearney, Seemantini Nadkarni, Farouc Jaffer

JBO, Vol. 16, Issue 02, 026005, (February 2011) https://doi.org/10.1117/12.10.1117/1.3533322

KEYWORDS: In vivo imaging, Speckle, Laser speckle imaging, Arteries, Speckle pattern, Prototyping, Blood, Electrocardiography, Motion measurement, Time metrology

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Proceedings Article | 18 May 2010 Paper

High resolution single-mode-fiber-based sensor for intravascular detection of fluorescent molecular probes

R. Nika Razansky, Mathias Mueller, Alexander Borisov, Alexander Koch, Farouc Jaffer, Vasilis Ntziachristos

Proceedings Volume 7715, 77152K (2010) https://doi.org/10.1117/12.854038

KEYWORDS: Sensors, Single mode fibers, Luminescence, GRIN lenses, Blood vessels, Head, Signal to noise ratio, Gaussian beams, Intravascular ultrasound, Polishing

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Early detection of coronary atherosclerosis is an unmet clinical challenge. The detection system has to be highly sensitive and possess high spacial resolution, in order to provide precise information of the vulnerable plaque location and size. Recently molecular fluorescence probes have been identified as efficient inflammation biomarkers for the inflammation process within vulnerable plaques¹ and being used in the proposed application to detect inflamed lesions in the blood vessel wall. The general principle of the proposed solution is based on a sensor whose head is guided by an intravascular catheter to the region of interest (coronary artery). When the sensor illuminates an activated fluorescent probe, located in inflamed areas of vulnerable plaques, the fluorescence is excited and light is emitted with a slightly shifted spectrum. The emitted light is being collected by the same sensor head, guided through the optical fiber and finally detected by photo-detectors. In this way, by detecting emitted fluorescence one can obtain information about the location of vulnerable plaques. The localization resolution is critically depending on the spot size of the illuminating light beam. Moreover, for a high signal to noise ratio in the detection electronics, as much fluorescent light as possible has to be collected from the plaque location. It has been already demonstrated that using single-mode fibers in combination with graded index fibers, a Gaussian beam, with adjustable waist position and diameter can be formed, representing the fundamental limit of achievable spot size². However, when using single mode fibers in this application, the collection efficiency would be very low due to the small core diameter of this fiber and thus signal to noise ratio would be strongly reduced. In this work, we present a solution to this challenge, combining both principles. A single mode fiber in combination with a graded index fiber is used for illumination purposes, while the fluorescence light is collected by the same fiber, but employing the cladding/coating total reflection to form a multimode fiber for the backwards propagating light. Thus, a narrow spot size can be obtained allowing high resolution images, with high signal to noise ratio due to the multimodal collection scheme. We show preliminary results of spot size and beam diameter measurements from the sensor head and discuss the implication for the improvement of the current catheter-based detection systems.

SPIE Journal Paper | 1 January 2010 Open Access

Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques

Marcella Calfon, Claudio Vinegoni, Vasilis Ntziachristos, Farouc Jaffer

JBO, Vol. 15, Issue 01, 011107, (January 2010) https://doi.org/10.1117/12.10.1117/1.3280282

KEYWORDS: Luminescence, Molecular imaging, In vivo imaging, Blood, Signal detection, Near infrared, Inflammation, Imaging systems, Arteries, Visualization

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SPIE Journal Paper | 1 March 2006 Open Access

Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy

Ashvin Pande, Rainer Kohler, Elena Aikawa, Ralph Weissleder, Farouc Jaffer

JBO, Vol. 11, Issue 02, 021009, (March 2006) https://doi.org/10.1117/12.10.1117/1.2186337

KEYWORDS: Luminescence, In vivo imaging, Microscopy, Nanoparticles, Laser scanners, Control systems, Arteries, Near infrared, Imaging systems, Reflectivity

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