Considering the considerable use of sedative drugs like methadone as a frequent substitution for additive drugs, we have investigated their effect on the cell activity via highly-resolved optical sensing method. Using plasmonic ellipsometry technique, a conspicuous shift in plasmonic resonance wavelength of the cultured chips was observed due to methadone presence during the cell culture of mesenchymal stem cells. This highly-sensitive platform can open new avenues towards the detection of drug effect on human cells and in large scale, on human organs.
Ring resonators based on photonic crystals have attracted worldwide attention due to their wide applications attributed to their significant properties. By comparing different inner rod configurations reported for photonic crystal ring resonators (PCRRs), we propose a configuration for inner rods similar to diamond, which is called the “diamond inner rod configuration.” In comparison with previous proposed configurations for inner rods, the diamond inner rod configuration increases the vertical waveguide output with respect to the horizontal waveguide. With this configuration a 50-50 output can be gained for two outputs, horizontal and vertical waveguides, at 1.829 and 1.6777 μm. Additionally, at 1.8438 μm there is a considerable drop toward a vertical waveguide. In order to have a comparison among the PCRRs with various inner rod configurations, the maximum power of outputs and also the quality factors have been shown schematically. To generalize our proposed configuration, in addition to a channel drop filter (CDF) based on a single-ring resonator, we designed a double-ring resonator in which the same powers can also be successively gained from three outputs at 1.876 μm by engineering the parameters of the structure.
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