The influence of size, geometry, temporal response of finite sensors and source geometry on the detected photoacoustic pressure is explored. We started considering the transducer simulated by a mesh of point-like sensors connected in parallel, which implies that appropriate modeling of pressure depends on the discretization size of the sensing surface. On the other hand, in analogy with the approach for the finite sensor, a finite source can be considered as a set of point like sources. We simulated the pressure produced by the linear, cylindrical and spherical source geometries, located at certain position over an axis perpendicular to the sensing surface. In order to simulate the photoacoustic signal, the computed pressure was convolved with the impulse response of two kind of commercial sensors: a low frequency transducer (3.5 MHz) and a high frequency transducer (125 MHz). Taking a fixed coordinate system we investigated the signal variations when the translational degree of freedom was modified. We found that simulated pressure generated by the different geometries using the proposed approach clearly differs from the point-like detection model.
The prognostic value of exposing malignant melanoma poses an urgent need for an efficient, accurate screening
method for metastatic cells. We propose a system for the detection of metastatic tumor cells based upon the
thermo-elastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection
system capable of exposing cells within the circulatory system in vitro. Initial trials provided a threshold on
the order of ten individual cells. Results imply the potential to assay simple blood draws for the presence of
cancerous melanoma providing an unprecedented method for routine cancer screening.
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