Polymer-based nanoparticles are promising contrast agents for photoacoustic (PA) imaging as their properties can be tailored to maximize detection sensitivity against the overwhelming endogenous background, while pump-probe excitation and fluence-dependent image acquisition may provide alternative approaches for contrast agent detection instead of multispectral imaging and unmixing. In this study, PA signals were measured in single-chain nanoparticle (SCNP) suspensions at pump and probe wavelengths of 690 nm and 730 nm and showed a strong nonlinear fluence dependence, which provides a unique contrast mechanism for molecular PA imaging.
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