Dr. Jay R. Knutson Profile

Dr. Jay R. Knutson

at National Heart Lung and Blood Institute

SPIE Involvement:

Author

Proceedings Article | 4 March 2022 Poster + Paper

Fluorescence lifetime imaging of metMyoglobin formation due to nitric oxide stress

Rozhin Penjweini, Mateus Mori, Paul Hwang, Dan Sackett, Jay Knutson

Proceedings Volume 11965, 119650H (2022) https://doi.org/10.1117/12.2608888

KEYWORDS: Fluorescence resonance energy transfer, Hypoxia, Oxygen, Sensors, Fluorescence lifetime imaging, NOx

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Proceedings Article | 4 March 2022 Poster + Presentation + Paper

metmyoglobin detection in mitochondria using fluorescence lifetime imaging of Citrine-Myoglobin-mCherry

Katie Link, Rozhin Penjweini, Alexandra Brown, Greg Alspaugh, Jay Chung, Jay Knutson

Proceedings Volume 11965, 119650K (2022) https://doi.org/10.1117/12.2626315

KEYWORDS: Fluorescence resonance energy transfer, Fluorescence lifetime imaging, Oxygen, Luminescence, Hypoxia, Sensors, Iron, Signal processing, Proteins, Microscopes

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Proceedings Article | 9 March 2020 Presentation

Optimization of analysis protocol and probe expression for monitoring intracellular oxygenation using fluorescence lifetime imaging of myoglobin-mCherry (Conference Presentation)

Rozhin Penjweini, Greg Alspaugh, Branden Roarke, Alexandra Chand, Jay Knutson

Proceedings Volume 11244, 112441T (2020) https://doi.org/10.1117/12.2550660

KEYWORDS: Fluorescence lifetime imaging, Fluorescence resonance energy transfer, Oxygen, Resonance energy transfer, Molecules, Molecular energy transfer, Molecular interactions, Pulsed laser operation, Luminescence, Absorbance

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Proceedings Article | 22 February 2019 Presentation + Paper

Genetically encoded FRET probes for direct mapping and quantification of intracellular oxygenation level via fluorescence lifetime imaging

Alessio Andreoni, Rozhin Penjweini, Branden Roarke, Marie-Paule Strub, Dan Sackett, Jay Knutson

Proceedings Volume 10882, 108820O (2019) https://doi.org/10.1117/12.2510646

KEYWORDS: Live cell imaging, Biosensing, Biosensors, Two photon imaging, Oxygen, Luminescence, Fluorescence lifetime imaging, Proteins, Sensors, Fluorescence resonance energy transfer, Absorption, Microscopes, Fluorescent proteins, In vitro testing

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Proceedings Article | 22 February 2019 Paper

Global analysis and Decay Associated Images (DAI) derived from Fluorescence Lifetime Imaging Microscopy (FLIM)

Mitchell Harling, Gregory Alspaugh, Alessio Andreoni, Aleksander Smirnov, Rozhin Penjweini, Michael Murphy, Marie-Paule Strub, Jay Knutson

Proceedings Volume 10882, 108822A (2019) https://doi.org/10.1117/12.2514365

KEYWORDS: Fluorescence lifetime imaging, Photons, Luminescence, Bacteria, Microscopy, Image analysis, Fluorescent proteins, Microscopes, LabVIEW, Image processing algorithms and systems, Image processing software, Data analysis, Two photon imaging, Two photon confocal microscopy

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SPIE Journal Paper | 8 October 2018 Open Access

Intracellular oxygen mapping using a myoglobin-mCherry probe with fluorescence lifetime imaging

Rozhin Penjweini, Alessio Andreoni, Tilman Rosales, Jeonghan Kim, Michael Brenner, Dan Sackett, Jay H. Chung, Jay Knutson

JBO, Vol. 23, Issue 10, 107001, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.107001

KEYWORDS: Oxygen, Luminescence, Fluorescence lifetime imaging, Proteins, Fluorescence resonance energy transfer, Tissues, Tissue optics, Microscopes, Energy transfer, Solids

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Proceedings Article | 28 July 2017 Paper

Visualizing the arterial wall water permeability barrier with femtosecond CARS microscopy

Bertrand Lucotte, Chloe Powell, Jay Knutson, Kim Dora, Robert Balaban

Proceedings Volume 10414, 104140L (2017) https://doi.org/10.1117/12.2285056

KEYWORDS: Multiphoton microscopy, Microscopy, Raman spectroscopy, Multiphoton processes, Physiology

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Proceedings Article | 4 March 2009 Paper

A hybrid global fitting algorithm for decay-associated images from fluorescence lifetime image microscopy data

Aleksandr Smirnov, Christian Combs, Robert Balaban, Kevin Tang, Jay Knutson

Proceedings Volume 7184, 71841D (2009) https://doi.org/10.1117/12.809844

KEYWORDS: Luminescence, Fluorescence lifetime imaging, Molecules, Microscopy, Biomedical optics, Linear algebra, Data modeling, Microscopes, Tissues, Image analysis

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Proceedings Article | 5 April 1996 Paper

Fluorescent photon migration theory for turbid biological media

Amir Gandjbakhche, Robert Bonner, Israel Gannot, Jay Knutson, Reza Navai, Ralph Nossal, George Weiss

Proceedings Volume 2679, (1996) https://doi.org/10.1117/12.237577

KEYWORDS: Modulation, Tissue optics, Phase shift keying, Absorption, Luminescence, Natural surfaces, Light scattering, Scattering, Algorithm development, Tissues

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Proceedings Article | 19 May 1994 Paper

Stationary low-coherence light-imaging and spectroscopy using a CCD camera

Alexander Knuettel, Joseph Schmitt, M. Shay, Jay Knutson

Proceedings Volume 2135, (1994) https://doi.org/10.1117/12.175998

KEYWORDS: Acousto-optics, Mirrors, Reflectometry, Charge-coupled devices, Spatial frequencies, Spectroscopy, CCD cameras, Interferometers, Sensors, Light emitting diodes

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Proceedings Article | 14 September 1993 Paper

Spatial localization using interfering photon density waves: contrast enhancement and limitations

Alexander Knuettel, Joseph Schmitt, R. Barnes, Jay Knutson

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154650

KEYWORDS: Signal detection, Modulation, Sensors, Destructive interference, Phase shift keying, CCD cameras, Scattering, Optical filters, Signal attenuation, Absorption

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Proceedings Article | 1 April 1992 Paper

Improvement of spatial resolution in reflectance near-infrared imaging by laser-beam interference

Alexander Knuettel, Joseph Schmitt, Jay Knutson

Proceedings Volume 1640, (1992) https://doi.org/10.1117/12.58232

KEYWORDS: Photons, Absorption, Destructive interference, Signal detection, Scattering, Sensors, Laser scattering, Phase measurement, Modulation, Laser spectroscopy

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Proceedings Article | 1 April 1992 Paper

Fluorescence quenching in proteins: some applications to protein-DNA and protein-lipid interactions

Jay Knutson, Raymond Chen, D. Porter, Preston Hensley, Myun Han, S. Kim, Samuel Wilson, M. Clague, Cynthia Williamson

Proceedings Volume 1640, (1992) https://doi.org/10.1117/12.58205

KEYWORDS: Luminescence, Proteins, Biochemistry, Laser spectroscopy, Polymers, Electronic design automation, Quantum efficiency, Calcium, Fluorescence resonance energy transfer, Energy transfer

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Proceedings Article | 1 May 1990 Paper

Applications of KINDK: following macromolecular processes with lifetimes

Susan Green, Preston Hensley, Jay Knutson

Proceedings Volume 1204, (1990) https://doi.org/10.1117/12.17687

KEYWORDS: Biochemistry, Proteins, Laser spectroscopy, Luminescence, Metals, Ions, Time resolved spectroscopy, Biological research, Genetics, Genetic engineering

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Showing 5 of 14 publications

Conference Committee Involvement (4)

7th NIH Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

15 September 2011 | Bethesda, Maryland, United States

Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

1 October 2009 | Bethesda, Maryland, United States

Optical Imaging 2006

25 September 2006 | Bethesda, Maryland, United States

Optical Imaging 2004

20 September 2004 | Washington, DC, United States

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