Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by lesions found in different regions of the central nervous system caused by overactive immune cells. MS also manifests in the retina, in which optic nerve pathology (such as optic neuritis) and neurodegenerative processes can affect inner retinal cells and structures. We observed the inner retina to be profoundly affected by MS, including nerve fiber bundle thinning, enlarged and lower density retinal ganglion cells, and the presence of microcysts. Longitudinal quantification of inner retinal changes enabled by AO-OCT may help accelerate the development of novel therapies for MS patients.
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