Dr. Lian He Profile

Dr. Lian He

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Proceedings Article | 5 March 2021 Presentation

In vivo quantification of placental hemodynamics with diffuse optical spectroscopy

Lin Wang, Jeffrey Cochran, Tiffany Ko, Wesley Baker, Kenneth Abramson, David Busch, Lian He, Arjun Yodh, Nadav Schwartz

Proceedings Volume 11639, 116390O (2021) https://doi.org/10.1117/12.2583369

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Currently, no bedside tool measures placental hemoglobin properties. Thus, we developed a hybrid optical/ultrasound (US) system to measure and study placental oxygen dynamics noninvasively. The system combines a Frequency-Domain Diffuse Optical Spectroscopy (FD-DOS) instrument that is capable of probing tissue as deep as 5 cm below the surface, with a commercial US device to provide synchronized tissue morphological information. Multi-layer models of photon diffusion are then utilized to reconstruct placental hemoglobin properties from FD-DOS data with morphological constraints from US. Phantom experiments, simulations, and studies in human subjects demonstrate that this instrument quantifies in vivo placental hemodynamics non-invasively.

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