Mr. Preston J. Leigh Profile

Preston J. Leigh

at Univ of Arizona

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Proceedings Article | 3 April 2024 Presentation + Paper

Few-shot tumor bud segmentation using generative model in colorectal carcinoma

Ziyu Su, Wei Chen, Preston Leigh, Usama Sajjad, Shuo Niu, Mostafa Rezapour, Wendy Frankel, Metin Gurcan, M. Khalid Khan Niazi

Proceedings Volume 12933, 129330A (2024) https://doi.org/10.1117/12.3006418

KEYWORDS: Image segmentation, Tumors, Data modeling, Cancer detection, Deep learning

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Current deep learning methods in histopathology are limited by the small amount of available data and time consumption in labeling the data. Colorectal cancer (CRC) tumor budding quantification performed using H&E-stained slides is crucial for cancer staging and prognosis but is subject to labor-intensive annotation and human bias. Thus, acquiring a large-scale, fully annotated dataset for training a tumor budding (TB) segmentation/detection system is difficult. Here, we present a DatasetGAN-based approach that can generate essentially an unlimited number of images with TB masks from a moderate number of unlabeled images and a few annotated images. The images generated by our model closely resemble the real colon tissue on H&E-stained slides. We test the performance of this model by training a downstream segmentation model, UNet++, on the generated images and masks. Our results show that the trained UNet++ model can achieve reasonable TB segmentation performance, especially at the instance level. This study demonstrates the potential of developing an annotation-efficient segmentation model for automatic TB detection and quantification.

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