Mr. Robert I. Loshkarev Profile

Robert I. Loshkarev

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 9 April 2020 Paper

Opening the BBB could disable neurovascular coupling: the quantitative mathematical model prediction

Robert Loshkarev, Dmitry Postnov

Proceedings Volume 11459, 114590Q (2020) https://doi.org/10.1117/12.2565794

KEYWORDS: Neurons, Potassium, Mathematical modeling, Blood brain barrier, Neurovascular coupling, Calcium, Ion channels, Receptors, Brain, Ions

Read Abstract +

The concept of neurovascular unit (NVU) is used to denote cells and their communication mechanisms involved in the formation of autoregulation of blood supply. It has been shown that the "opening" of blood-brain barrier (BBB) can be caused by different types of effects, such as a strong and prolonged sound, or by laser irradiation. It has been noted that the BBB opening is accompanied by perivascular edema, as capillary permeability to water also increases many times. Thus, one can expect that such changes can significantly affect the operational mode of neurovascular unit. We present the model study aimed to estimate the impact of perivascular edema on the functioning of neurovascular coupling using a multidimensional quantitative mathematical model. Our results predict the blocking of neurovascular communication operation when BBB is opened. Namely, we show that a relatively small (2-3 times) change in perivascular volume has a subtle effect, a 10-fold increase in PVS changes markedly, but does not violate the functionality of neurovascular coupling, and a significant degree of edema (increase in PVS more than 100 times) almost completely turns off the neurovascular coupling.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years