Prof. Tianhong Dai Profile

Prof. Tianhong Dai

Associate Professor at Mass General Hospital, Harvard Medical School

SPIE Involvement:

Conference Chair | Editor | Author | Special Event Speaker

Publications (27)

Proceedings Article | 22 March 2024 Poster

Synergistic killing of Staphylococcus aureus by the combination of cold atmospheric plasma and antimicrobial blue light

Gizem Dilara Ozdemir, Tianhong Dai, Utku Kursat Ercan, Carolina dos Anjos

Proceedings Volume PC12822, PC128220U (2024) https://doi.org/10.1117/12.3001824

KEYWORDS: Atmospheric plasma, Biofilms, Resistance, Plasma treatment, Luminescence, Biomedical applications

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Proceedings Article | 13 March 2024 Poster

Potassium selenocyanate potentiates both antimicrobial blue light and antimicrobial photodynamic inactivation against Gram-negative bacteria

Min Wu, Tianhong Dai, Carolina dos Anjos, Jiaqi Weng

Proceedings Volume PC12822, PC128220Z (2024) https://doi.org/10.1117/12.3023279

KEYWORDS: Potassium, Bacteria, Scanning electron microscopy, Resistance, Confocal microscopy, Clinical trials, Biofilms

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Proceedings Article | 13 March 2024 Presentation

Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device

Pu-Ting Dong, Laisa Negri, Ying Wang, Joshua Tam, Tianhong Dai, Rox Anderson, Jie Hui, Seok-Hyun Andy Yun, Jeff Gelfand, Wonjoon Moon, Carolina dos Anjos, Hao Yan, Jeremy Goverman

Proceedings Volume PC12822, PC128220I (2024) https://doi.org/10.1117/12.3001119

KEYWORDS: Skin, Control systems, In vivo imaging, Wound healing, Thermal effects, Resistance, Light sources and illumination, Biomedical applications, Windows, Wearable devices

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Proceedings Article | 13 March 2024 Presentation

Antimicrobial blue light activatable optical-tympanostomy tube: a novel alternative to control tympanostomy tube otorrhea

Carolina dos Anjos, Vishakha Sabharwal, Soroush Shabahang, Gizem Dilara Ozdemir, Yazdani Shaik-Dasthagirisaheb, Stephen Pelton, Tianhong Dai, Loc Truong

Proceedings Volume PC12822, PC128220J (2024) https://doi.org/10.1117/12.3003562

KEYWORDS: Biofilms, Optical surfaces, Therapeutics, Light emitting diodes, In vitro testing, Animals, Animal model studies

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Proceedings Article | 17 March 2023 Presentation

Antimicrobial blue light promotes an important role in enzymatic activity and degradation of β-lactamases.

Carolina dos Anjos, Rox Anderson, Tianhong Dai, Leon Leanse

Proceedings Volume PC12358, PC123580B (2023) https://doi.org/10.1117/12.2651168

KEYWORDS: Bacteria, Resistance, Proteins, Microorganisms

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Proceedings Article | 17 March 2023 Presentation

Blue light enhances antibiotic activity in multidrug-resistant bacteria

Rox Anderson, David Hooper, Tianhong Dai, Leon Leanse, Carolina dos Anjos

Proceedings Volume PC12358, PC123580A (2023) https://doi.org/10.1117/12.2655368

KEYWORDS: Bacteria, Pathogens, Switches, Resistance, Oxygen, Microorganisms, Medicine

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Proceedings Article | 7 March 2022 Presentation

Blue light is a multi-purpose antibiotic adjuvant that synergizes with conventional antibiotic therapy

Leon Leanse, Carolina dos Anjos, Tianhong Dai

Proceedings Volume PC11939, PC1193906 (2022) https://doi.org/10.1117/12.2609760

KEYWORDS: Bacteria, Resistance, Phototherapy, In vitro testing, Pathogens, Oxygen, Mode conditioning cables, Microorganisms, Medicine, Light emitting diodes

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Proceedings Article | 7 March 2022 Presentation

Antimicrobial blue light for prevention of lethal Vibrio vulnificus infection in mice

Leon Leanse, Richard Anderson, Tianhong Dai, Carolina dos Anjos

Proceedings Volume PC11939, PC1193908 (2022) https://doi.org/10.1117/12.2610455

KEYWORDS: In vitro testing, Resistance, Oceanography, In vivo imaging, Bioluminescence

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Proceedings Article | 5 March 2021 Presentation

Dual-wavelength photo-killing of methicillin resistant staphylococcus aureus

Leon Leanse, Xueping Sharon Goh, David Hooper, Tianhong Dai, Ji-Xin Cheng

Proceedings Volume 11626, 116260T (2021) https://doi.org/10.1117/12.2577202

KEYWORDS: Skin, Photolysis, Oxygen, In vivo imaging, Cell death, Tissues, Tissue optics, Resistance, Photomedicine, Organisms

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Proceedings Article | 10 March 2020 Presentation

Photoinactivation of otopathogens using 405 nm blue light: Implications for the treatment of otitis media (Conference Presentation)

Xiaojing Liu, Qihang Chang, Raquel Ferrer-Espada, Leon Leanse, Xueping Goh, Xiuli Wang, Jeffrey Gelfand, Tianhong Dai

Proceedings Volume 11223, 112230N (2020) https://doi.org/10.1117/12.2546695

KEYWORDS: Transmission electron microscopy, Liquids, Chromatography, Animal model studies

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Proceedings Article | 7 March 2019 Presentation + Paper

Photo-inactivation of Neisseria gonorrhoeae: a paradigm changing approach for combating antibiotic-resistant gonococcal infections

Tianhong Dai, Yonatan Grad, Jeffrey Gelfand, Ying Wang, Raquel Ferrer-Espada, Yan Baglo, Xueping Goh, Ying Gu, Kathryn Held

Proceedings Volume 10863, 108630T (2019) https://doi.org/10.1117/12.2505736

KEYWORDS: Resistance, Bacteria, Toxicity, Confocal microscopy, Phototherapy, Pathogens

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Proceedings Article | 7 March 2019 Paper

Evaluating the potential for resistance development in Gram-negative bacteria to antimicrobial blue light (at 405 nm): in vitro and in vivo studies

Leon Leanse, Olivia Harrington, Xueping Sharon Goh, Tianhong Dai, Yanyan Fang, Imran Ahmed

Proceedings Volume 10863, 1086318 (2019) https://doi.org/10.1117/12.2506910

KEYWORDS: Resistance, In vitro testing, Bacteria, In vivo imaging, Pathogens, Organisms, Tissues, Microorganisms, Standards development, Stochastic processes

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Proceedings Article | 7 March 2019 Presentation + Paper

Synergistic inactivation of multidrug-resistant Pseudomonas aeruginosa by essential oil and blue light

Min Lu, Tianhong Dai, Mei Wu

Proceedings Volume 10863, 108630Z (2019) https://doi.org/10.1117/12.2507035

KEYWORDS: Bacteria, In vitro testing, Chemical analysis, Resistance, Luminescence, In vivo imaging, Microbiology, Bioluminescence, Skin

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Proceedings Article | 7 March 2019 Paper

Synergistic effect of antimicrobial blue light (at 405 nm) and quinine against multidrug-resistant infections: in vitro and in vivo studies

Leon Leanse, Pu-Ting Dong, Ji-Xin Cheng, Min Lu, Y. Wang, Xueping Sharon Goh, Tianhong Dai, David Hooper

Proceedings Volume 10863, 108630Y (2019) https://doi.org/10.1117/12.2506033

KEYWORDS: In vivo imaging, Skin, In vitro testing, Raman spectroscopy, Tissues, Bacteria, Pathogens, Scanning electron microscopy, Laser therapeutics, Resistance

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Proceedings Article | 4 March 2019 Presentation

Drug-resistant catheter-associated urinary tract Infection (CAUTI): an enlightened therapeutic approach (Conference Presentation)

Anton Wintner, Jeffery Gelfand, Yingying Huang, Rox Anderson, Michael Hamblin, Timothy Brauns, Patrick Seed, Tianhong Dai

Proceedings Volume 10863, 108630P (2019) https://doi.org/10.1117/12.2507562

KEYWORDS: Resistance, Bladder, Photodynamic therapy, Potassium, Fiber lasers, In vitro testing

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Proceedings Article | 14 March 2018 Presentation

Decacationic [70]fullerenyl-light harvesting chromophore conjugates for efficient photokilling of infectious bacteria (Conference Presentation)

Long Chiang, Ying-Ying Huang, Min Wang, Liyi Huang, Tianhong Dai, Michael Hamblin

Proceedings Volume 10479, 104790Y (2018) https://doi.org/10.1117/12.2289070

KEYWORDS: Pathogens, Chromophores, Bacteria, Photochemistry, Oxygen, Fullerenes

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Proceedings Article | 8 February 2018 Presentation + Paper

Antimicrobial blue light inactivation of Neisseria gonorrhoeae

Ying Wang, Tianhong Dai, Ying Gu

Proceedings Volume 10479, 104790O (2018) https://doi.org/10.1117/12.2291545

KEYWORDS: Absorption, Bacteria, Resistance, Absorption spectroscopy, Fluorescence spectroscopy, Spectroscopy

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Proceedings Article | 8 February 2018 Paper

Antimicrobial blue light inactivation of biofilms formed by clinical isolates of multidrug-resistant microorganisms

Yanyan Fang, Tianhong Dai, Raquel Ferrer-Espada

Proceedings Volume 10479, 104790N (2018) https://doi.org/10.1117/12.2288520

KEYWORDS: Microorganisms, Confocal microscopy, Resistance, Pathogens, Bacteria, Fungi, Light emitting diodes, Microscopy

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Proceedings Article | 8 February 2018 Presentation + Paper

Antimicrobial blue light: a drug-free approach for inactivating pathogenic microbes

Tianhong Dai, Ying Wang

Proceedings Volume 10479, 104790J (2018) https://doi.org/10.1117/12.2283019

KEYWORDS: Microorganisms, Pathogens, Oxygen, In vivo imaging, Light emitting diodes, Medicine, Phototherapy, Laser therapeutics, Visible radiation, Antimicrobial agents

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Proceedings Article | 31 October 2016 Paper

Antimicrobial blue light inactivation of Methicillin-resistant Staphylococcus aureus

Yucheng Wang, Tianhong Dai, Ying Gu

Proceedings Volume 10024, 100241H (2016) https://doi.org/10.1117/12.2246533

KEYWORDS: Bacteria, In vivo imaging, In vitro testing, Bioluminescence, Mouse models, Luminescence, Light emitting diodes, Imaging systems, Medicine, Cameras

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Proceedings Article | 22 May 2015 Paper

Antimicrobial blue light therapy for Candida albicans burn infection in mice

Tianhong Dai, Yunsong Zhang, Yucheng Wang, Michael Hamblin, Ying Gu, Clinton Murray

Proceedings Volume 9467, 94670K (2015) https://doi.org/10.1117/12.2178232

KEYWORDS: Phototherapy, Luminescence, Resistance, In vitro testing, Bioluminescence, Statistical analysis, In vivo imaging, Light emitting diodes, Real time imaging, Pathogens

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Proceedings Article | 9 February 2012 Paper

Photodynamic therapy can induce non-specific protective immunity against a bacterial infection

Pawel Mroz, Manabu Kinoshita, Michael Hamblin, Yuji Morimoto, Masamitsu Tanaka, Tianhong Dai

Proceedings Volume 8224, 822403 (2012) https://doi.org/10.1117/12.906012

KEYWORDS: Photodynamic therapy, Bacteria, Tissues, Defense and security, Image processing, Light emitting diodes, In vivo imaging, Statistical analysis, Data analysis, Surgery

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Proceedings Article | 13 July 2009 Paper

Antimicrobial photodynamic therapy in a mouse model of Acinetobacter baumannii burn infection

George Tegos, Michael Franklin, Liyi Huang, Zongshun Lu, David Baer, Michael Hamblin, Tianhong Dai, Timur Zhiyentayev

Proceedings Volume 7380, 738037 (2009) https://doi.org/10.1117/12.823065

KEYWORDS: Photodynamic therapy, Luminescence, Picosecond phenomena, Wound healing, Bacteria, Mouse models, Bioluminescence, Blood, Visible radiation, Light emitting diodes

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Proceedings Article | 21 February 2007 Paper

Low-level light therapy for Zymosan induced arthritis in rats

William Apruzzese, Anna Yaroslavsky, Richard Cohen, Michael Smotrich, Ilya Yaroslavsky, Ana Castano, Elena Salomatina, Tatiana Demidova-Rice, Michael Hamblin, Tianhong Dai

Proceedings Volume 6428, 64280F (2007) https://doi.org/10.1117/12.698193

KEYWORDS: Wound healing, Laser therapeutics, Low level phototherapy, Inflammation, Animal model studies, Phototherapy, Chromophores, Acquisition tracking and pointing, Near infrared, Medicine

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SPIE Journal Paper | 1 July 2006 Open Access

Comparative study of cryogen spray cooling with R-134a and R-404a: implications for laser treatment of dark human skin

Tianhong Dai, Mohammad Yaseen, Parmeswaran Diagaradjane, David Chang, Bahman Anvari

JBO, Vol. 11, Issue 04, 041116, (July 2006) https://doi.org/10.1117/12.10.1117/1.2338001

KEYWORDS: Skin, Cryogenics, Injuries, Blood vessels, Temperature metrology, Ear, Laser irradiation, Laser therapeutics, In vivo imaging, In vitro testing

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Cutaneous laser treatment in dark skin patients is challenging due to significant light absorption by the melanin at the basal layer of epidermis, which can result in irreversible nonspecific thermal injury to the epidermis. Cryogen spray cooling (CSC) with R-134a (boiling point –26.2°C at 1 atm), which is currently used during cutaneous laser treatment, has shown poor efficacy in protecting dark human skin. We investigated the potential of CSC with R-404a (boiling point –46.5°C at 1 atm), which has a lower boiling point than R-134a, for improved therapeutic outcome in dark human skin at three levels: in vitro (epoxy resin skin phantom), ex vivo (normal dark human skin sample), and in vivo (skin of the rabbit external ear). The skin phantom was used to acquire the surface and internal temperature profiles in response to CSC with R-134a or R-404a at various spurt durations, based upon which CSC-induced heat removal from the skin phantom was estimated using an algorithm that solved a one-dimensional inverse heat conduction problem. CSC with R-404a increased the temperature reductions within the phantom and subsequently the amount of heat removal from the phantom in comparison to that with R-134a. Normal ex vivo Fitzpatrick types V-VI human skin samples were used to investigate the thermal response of dark human skin epidermis to CSC (R-134a or R-404a) at various spurt durations in conjunction with 595-nm pulsed dye laser irradiation at various radiant exposures. Cryogen R-404a increased the threshold radiant exposures for irreversible thermal injury to the epidermis in dark pigmentation skin. No obvious CSC-induced morphological changes to human skin was observed when sprayed with R404-a spurts using durations up to 300 ms. In vivo rabbit ear vasculature was used as a model of cutaneous anomalies to assess the influences of CSC (with R-134a or R-404a) on the photothermolysis of dermal blood vessels. CSC (R-134a or R-404a) with the spurt durations of 100 to 300 ms increased the most superficial depth of ...

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Proceedings Article | 13 July 2004 Paper

A theoretical investigation of human skin thermal response to near-infrared laser irradiation

Tianhong Dai, Lihong Wang, Bahman Anvari, Brian Pikkula

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.529146

KEYWORDS: Skin, Blood vessels, Blood, Absorption, Pulsed laser operation, Cryogenics, Laser irradiation, Scattering, Optical properties, Laser damage threshold

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Proceedings Article | 12 September 2003 Paper

Thermal response of human skin epidermis in different skin types to 595-nm laser irradiation and cryogen spray cooling: an ex-vivo study

Bahman Anvari, David Chang, Brian Pikkula, James Tunnell, Tianhong Dai

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476134

KEYWORDS: Skin, Injuries, Blood vessels, Cryogenics, Laser irradiation, Pulsed laser operation, Laser therapeutics, In vivo imaging, Laser coagulation, Dye lasers

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