According to their high electron density and ultrasmall size, gold nanoclusters (AuNCs) have unique luminescence and photoelectrochemical properties that make them very attractive for various biomedical fields. We present an overview of the interaction between ultrasmall luminescent gold nanoclusters and lipidic membranes through electrostatic attraction, showing that it is possible to induce a large change in membrane structures or not. An efficient method was developed to encapsulate them into vesicle for drug delivery. These probes are easily internalized into cells through specific membrane protein targeting and also in vivo organisms.
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