Quantum correlation is critical in quantum information applications, and numerous inequalities have been established to quantify the non-classical correlations such as the Bell nonlocality and quantum steering. We introduce an experimental method to map full-domain correlation for nonlocality and quantum steering in the Clauser-Horne-Shimony-Holt scenarios. This approach accounts for detection imperfections and simplifies interpretations, answering fundamental questions about nonlocality and quantum steering. Additionally, we illustrate its utility in calibrating an entanglement-based quantum key distribution protocol with arbitrary bipartite states. Our correlation maps offer a direct, straightforward contribution to quantum information applications.
We introduce quantum microscopy by coincidence (QMC) featuring balanced pathlengths, which facilitates super-resolution imaging at the Heisenberg limit, drastically boosting speed and contrast-to-noise ratio (CNR) compared to existing wide-field quantum imaging methods. QMC uses correlated photons traversing symmetric paths, behaving like a photon with half the wavelength for twice the resolution. It withstands 155 times stronger stray light than classical signals, promising non-destructive bioimaging. Our approach propels quantum imaging to microscopic scale by imaging cancer cells. Experimental and theoretical results endorse this balanced pathlength configuration as a path to quantum-enhanced coincidence imaging at the Heisenberg limit.
As the most prevalent hepatic disorder worldwide, non-alcoholic fatty liver disease strongly correlates to obesity and encompasses a broad spectrum from steatosis to carcinoma. Complementary to established diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with endogenous optical contrast. However, none of the PAT systems has investigated fatty liver non-invasively with detailed angiograms. With the newly developed noninvasive PAT (termed 3D-PAT) system, we study the livers of multiple rats in vivo. The system provides isotropically high spatial resolution in 3D space, presenting clear anatomical and dynamical details of the rat livers. Moreover, we propose several PAT image features to quantify the difference between the livers of lean and obese rats. Statistical differences between the two groups have been observed, demonstrating the capabilities of 3D-PAT to provide hematogenous information for fatty liver diagnosis. The preclinical hepatic research using 3D-PAT warrants clinical translation towards human pediatric liver imaging.
Combining functional optical contrast with high spatiotemporal resolution, photoacoustic computed tomography (PACT) benefits mainstream cardiac imaging modalities for preclinical research. However, PACT has not revealed detailed vasculature or hemodynamics of the whole heart without surgical tissue penetration. Here, we present non-invasive imaging of rat hearts using the recently developed three-dimensional PACT (3D-PACT) platform. 3D-PACT utilizes optimized illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall, thus visualizing cardiac anatomy and intracardiac hemodynamics within a 10-second scan. We then applied 3D-PACT to investigate different structural and functional variations in healthy, hypertensive, and obese rat hearts. 3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing animal models, holding promises for clinical translation to human neonatal cardiac imaging without sedation or ionizing radiation.
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