KEYWORDS: Brain, Neuroimaging, Hemodynamics, Acquisition tracking and pointing, Photoacoustic tomography, Photoacoustic spectroscopy, In vivo imaging, Brain mapping, Visualization, Imaging systems
While medical imaging is playing an increasingly important role in understanding and clarifying acupuncture theory in general, it is still challenging to systematically understand the operational mechanisms of acupuncture on the central and peripheral nerve systems using the existing acupuncture imaging tools. Here, we report an application of photoacoustic tomography (PAT) to mapping cerebral hemodynamics response to acupuncture in mice. Huantiao acupoint (GB 30) is selected as the stimulating points in this study. In vivo photoacoustic images of cerebral hemodynamics response to acupuncture are obtained in ten functional regions of a mouse brain. Real-time photoacoustic signal changes in brain cortex and dynamic changes in total hemoglobin (HbT) concentration are tracked at 532 nm. Our results suggest that PAT provides imaging basis on cerebral hemodynamic response to acupuncture, and may have great potential for understanding the operational mechanisms of acupuncture on the central nerve systems.
Rheumatoid arthritis (RA) is the leading cause of disability among people over 50-year-old. However, the diagnosis of RA is a complex problem because of the complexity of symptoms and structures. While current clinical imaging techniques play an important role in the diagnosis of RA, they do have several limitations. As an emerging hybrid modality, thermoacoustic tomography (TAT) provides high electromagnetic contrast and high ultrasonic resolution. Our early work showed that TAT could provide high quality anatomic structures of peripheral joints in healthy human fingers. In this study, we applied TAT to the detection of RA in the finger joint. Ultrasound imaging (US) was performed to verify TAT findings. The TAT images of the RA joint displayed abnormalities compared to the healthy ones, and they matched well with the US images. The initial results demonstrate that TAT has the potential to be conducive to detection of RA in vivo, which also provide a foundation for its clinical application to the diagnosis of RA.
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