Noninvasive OCTA-based blood glucometry

Kaiyuan Liu; Tiepei Zhu; Lin Yao; Ziyi Zhang; Huakun Li; Juan Ye; Peng Li

doi:10.1117/12.2612328

2 March 2022 Noninvasive OCTA-based blood glucometry

Kaiyuan Liu, Tiepei Zhu, Lin Yao, Ziyi Zhang, Huakun Li, Juan Ye, Peng Li

Proceedings Volume PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX; PC1195902 (2022) https://doi.org/10.1117/12.2612328
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We investigated the correlation of the blood optical attenuation coefficient (OAC) and the blood glucose concentration (BGC). The blood OAC was measured in mouse retina in vivo through OCT angiography (OCTA). The arteries and veins presented a blood OAC change of ~0.05-0.07 mm-1 per 10 mg/dl and a significant elevation of blood OAC in diabetic mice was observed. Besides, the veins had a higher correlation coefficient between the measured blood OAC and BGC than that of the arteries. The blood OAC-BGC correlation suggests a concept of non-invasive OCTA-based glucometry, allowing a fast assessment of the blood glucose of specific vessels.

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Citation Download Citation

Kaiyuan Liu, Tiepei Zhu, Lin Yao, Ziyi Zhang, Huakun Li, Juan Ye, and Peng Li "Noninvasive OCTA-based blood glucometry", Proc. SPIE PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX, PC1195902 (2 March 2022); https://doi.org/10.1117/12.2612328

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KEYWORDS

Blood

Glucose

Retina

Signal attenuation

Arteries

Veins

In vivo imaging

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