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28 September 2023 Quantum diamond voltage microscopy for bio-imaging applications
David A. Simpson
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Proceedings Volume PC12657, Quantum Nanophotonic Materials, Devices, and Systems 2023; PC126570C (2023) https://doi.org/10.1117/12.2682770
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States
Abstract
The development of fluorescent molecular sensors for imaging voltage changes in biological systems has revolutionized neuroscience over the past decade. However, the poor photostability of molecular voltage sensors limits recording times to a few minutes, posing problems for longitudinal studies of network evolution and disease processes. These limitations have led to the uptake of lower-resolution extracellular recording techniques such as multi-electrode arrays (MEAs) for long term neurological research. Here, we present an alternate platform for sensitive high resolution voltage imaging using fluorescent, charge-sensitive defects in a transparent diamond substrate. We demonstrate how this sensing modality can be used to image sub-millivolt signals over millisecond timescales opening new pathways for 2D and 3D neurological imaging applications.
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David A. Simpson "Quantum diamond voltage microscopy for bio-imaging applications", Proc. SPIE PC12657, Quantum Nanophotonic Materials, Devices, and Systems 2023, PC126570C (28 September 2023); https://doi.org/10.1117/12.2682770
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KEYWORDS
Diamond
Biological imaging
Microscopy
Neuroscience
Quantum sensors
Fluorescence
Image resolution
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