Semiconducting polymer dot as a highly effective contrast agent for photoacoustic imaging

Zhen Yuan; Jian Zhang

doi:10.1117/12.2286796

19 February 2018 Semiconducting polymer dot as a highly effective contrast agent for photoacoustic imaging

Zhen Yuan, Jian Zhang

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104944F (2018) https://doi.org/10.1117/12.2286796
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

In this study, we developed a novel PIID-DTBT based semiconducting polymer dots (Pdots) that have broad and strong optical absorption in the visible-light region (500 nm - 700 nm). Gold nanoparticles (GNPs) and gold nanorods (GNRs) that have been verified as an excellent photoacoustic contrast agent were compared with Pdots based on photoacoustic imaging method. Both ex vivo and in vivo experiment demonstrated Pdots have a better photoacoustic conversion efficiency at 532 nm than GNPs and similar photoacoustic performance with GNRs at 700 nm at the same mass concentration. Our work demonstrates the great potential of Pdots as a highly effective contrast agent for precise localization of lesions relative to the blood vessels based on photoacoustic tomography imaging.

Citation Download Citation

Zhen Yuan and Jian Zhang "Semiconducting polymer dot as a highly effective contrast agent for photoacoustic imaging", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104944F (19 February 2018); https://doi.org/10.1117/12.2286796

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