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7 March 2019 Photo-inactivation of Neisseria gonorrhoeae: a paradigm changing approach for combating antibiotic-resistant gonococcal infections
Ying Wang, Raquel Ferrer-Espada, Yan Baglo, Xueping S. Goh, Kathryn D. Held, Yonatan H. Grad, Ying Gu, Jeffrey A. Gelfand, Tianhong Dai
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Proceedings Volume 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II; 108630T (2019) https://doi.org/10.1117/12.2505736
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Antimicrobial resistance in Neisseria gonorrhoeae is a major issue of public health, and there is a critical need for the development of new anti-gonococcal strategies. In this study, we investigated the effectiveness of antimicrobial blue light (aBL; 405 nm wavelength), an innovative non-pharmacological approach, for the inactivation of N. gonorrhoeae. Our findings indicated that aBL preferentially inactivated N. gonorrhoeae, including antibiotic-resistant strains, over human vaginal epithelial cells in vitro. Furthermore, no genotoxicity of aBL to the vaginal epithelial cells was observed at the radiant exposure for inactivating N. gonorrhoeae. aBL also effectively inactivated N. gonorrhoeae that had attached to and invaded into the vaginal epithelial cells in their co-cultures. No gonococcal resistance to aBL developed after 15 successive cycles of sub-therapeutic aBL inactivation. Taken together, aBL represents a potent potential treatment for antibiotic-resistant gonococcal infection.
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Ying Wang, Raquel Ferrer-Espada, Yan Baglo, Xueping S. Goh, Kathryn D. Held, Yonatan H. Grad, Ying Gu, Jeffrey A. Gelfand, and Tianhong Dai "Photo-inactivation of Neisseria gonorrhoeae: a paradigm changing approach for combating antibiotic-resistant gonococcal infections", Proc. SPIE 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II, 108630T (7 March 2019); https://doi.org/10.1117/12.2505736
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KEYWORDS
Resistance
Bacteria
Confocal microscopy
Toxicity
Pathogens
Phototherapy
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