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4 March 2019 NIRS measurements of muscle oximetry in the obese (Conference Presentation)
Andres Rodriguez, Tananant Boonya-ananta, Alex Garrido, Jacob Lopez, Jessica Ramella-Roman
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Proceedings Volume 10877, Dynamics and Fluctuations in Biomedical Photonics XVI; 108770M (2019) https://doi.org/10.1117/12.2508612
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Obesity is a pandemic affecting more than 93 million adults in the U.S. Obese are defined as individuals with a Body Mass Index (BMI) of 30 or more. Several studies are demonstrating that this weight-to-height ratio does not fully characterize the patient’s pathophysiology. Monitoring muscle metabolism, the synthesis and breakdown of muscle protein, may be a more useful metric in the characterization of pathologies associated to weight gain. Long term imbalances of energy intake to energy expenditures lead to obesity. Total expenditure is the summation of energies related to the thermic effect of food, activity, and resting expenditure. While at rest, muscle metabolism is the primary component of resting energy expenditure.Daily energy release in muscle mass could significantly lead a net-loss of fat in the long-run, and thus potentially contribute to the prevention of obesity. Near Infrared Spectroscopy (NIRS) measurement of muscle oxygenation can be used to study muscle metabolism. NIRS has the advantage of being a non-invasive, reproducible, and inexpensive methodology. Unfortunately, commercial NIRS system fail to produce accurate results in the obese population due to excess adipose thicknesses (AT) that alter the optical signal. We have used Monte Carlo models of light transfer to probe the optimal source-detector separation necessary to use NIRS in the obese. We have also developed a low-cost wearable muscle oximeter targeted to individuals with high BMI. We will demonstrate our system validation in optical phantoms and volunteers.
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Andres Rodriguez, Tananant Boonya-ananta, Alex Garrido, Jacob Lopez, and Jessica Ramella-Roman "NIRS measurements of muscle oximetry in the obese (Conference Presentation)", Proc. SPIE 10877, Dynamics and Fluctuations in Biomedical Photonics XVI, 108770M (4 March 2019); https://doi.org/10.1117/12.2508612
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KEYWORDS
Near infrared spectroscopy
Oximetry
Mode conditioning cables
Lead
Light
Monte Carlo methods
Oximeters
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