Photoacoustic monitoring of tissue temperature at high temporal resolution

Paul Kumar Upputuri; Manojit Pramanik

doi:10.1117/12.2508284

27 February 2019 Photoacoustic monitoring of tissue temperature at high temporal resolution

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 1087832 (2019) https://doi.org/10.1117/12.2508284
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Monitoring of tissue temperature is necessary for guiding energy-based medical treatments. The local temperature information is also important for the safe deposition of light/heat energy into the surrounding healthy tissue. Existing imaging modalities fail to monitor tissue temperature with high accuracy and high resolution. Photoacoustic sensing of temperature was demonstrated using Q-switched Nd:YAG laser. A temperature sensitivity of ~0.15°C was obtained at a temporal resolution of ~2 s. Photoacoustic imaging is a high-speed, high-resolution, deep tissue imaging modality for both preclinical and clinical applications. In this work, we demonstrate photoacoustic sensing of temperature at high temporal resolution order of microseconds using high repetition rate (7000 Hz) near-infrared (~803 nm) pulsed laser diodes. The system will find applications in radiation therapy, photothermal therapy, photodynamic therapy, etc.

Citation Download Citation

Paul Kumar Upputuri and Manojit Pramanik "Photoacoustic monitoring of tissue temperature at high temporal resolution", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 1087832 (27 February 2019); https://doi.org/10.1117/12.2508284

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KEYWORDS

Photoacoustic spectroscopy

Temporal resolution

Semiconductor lasers

Ultrasonography

Tissue optics

Tissues

Photodynamic therapy

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