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7 March 2019 Treatment of pancreatic tumors using combination of laser irradiation and immunological stimulation (Conference Presentation)
Wei R. Chen, Jingxuan Yang, Min Li, Feifan Zhou, Meng Wang
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Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 1087907 (2019) https://doi.org/10.1117/12.2506731
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Pancreatic cancer is one of the most challenging diseases. Patients with metastatic pancreatic cancer has a poor prognosis with a 3% five-year survival rate. The high mortality rate is largely due to two major factors: the severely limited resectability and extremely high rate of metastasis. We applied laser immunotherapy (LIT) to treat a highly metastatic, poorly immunogenic pancreatic tumor model (Panc02-H7) in mice. Subcutaneous tumors were irradiated by a near-infrared laser non-invasively and orthotopic tumors were irradiated by the laser interstitially, followed by intratumoral injection of glycated chitosan, an immunoadjuvant. Long-term survival and tumor-specific immunity were observed after LIT treatment. The effectiveness of LIT in treating pancreatic tumors demonstrated in this study could lead to a feasible modality for this deadly disease.
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Wei R. Chen, Jingxuan Yang, Min Li, Feifan Zhou, and Meng Wang "Treatment of pancreatic tumors using combination of laser irradiation and immunological stimulation (Conference Presentation)", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087907 (7 March 2019); https://doi.org/10.1117/12.2506731
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KEYWORDS
Tumors
Laser irradiation
Pancreatic cancer
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