Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment

A. Sdobnov; A. Bykov; A. Popov; I. Lihacova; A. Lihachev; J. Spigulis; I. Meglinski

doi:10.1117/12.2526921

22 July 2019 Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment

A. Sdobnov, A. Bykov, A. Popov, I. Lihacova, A. Lihachev, J. Spigulis, I. Meglinski

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110751F (2019) https://doi.org/10.1117/12.2526921
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Laser Speckle Contrast Imaging (LSCI) is a powerful low-cost method for visualization of flow, microcirculation and blood perfusion. Due to the fact that diseased and healthy tissues has different blood perfusion, LSCI can be a perspective tool for cancer diagnostics and discrimination between different types of tissues. Previously, multispectral diffuse reflectance imaging method for melanoma diagnostics has been introduced. In this work, multi-wavelength (532-, 655- and 850- nm) LSCI technique combined with hyperspectral camera and diffuse reflectance imaging method will be used for assessment of tissues with different skin perfusion properties. An in vivo experiment with occlusion in human finger was performed serving as a model of tissues with different perfusion properties. The proposed method still requires further development and improvements to become a real clinical laboratory tool for non-invasive skin cancer diagnostics.

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A. Sdobnov, A. Bykov, A. Popov, I. Lihacova, A. Lihachev, J. Spigulis, and I. Meglinski "Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751F (22 July 2019); https://doi.org/10.1117/12.2526921

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