Characterization of modified agave fructans used as drug carriers to the colon by spectroscopy techniques

Carmen Miramontes-Corona; Marco A. Escalante; Ezequiel Delgado; Rosa I. Corona-González; Humberto Vázquez-Torres; Guillermo Toriz

doi:10.1117/12.2526135

9 September 2019 Characterization of modified agave fructans used as drug carriers to the colon by spectroscopy techniques

Carmen Miramontes-Corona, Marco A. Escalante, Ezequiel Delgado, Rosa I. Corona-González, Humberto Vázquez-Torres, Guillermo Toriz

Author Affiliations +

Proceedings Volume 11128, Infrared Remote Sensing and Instrumentation XXVII; 111280X (2019) https://doi.org/10.1117/12.2526135
Event: SPIE Optical Engineering + Applications, 2019, San Diego, California, United States

Abstract

Carbohydrate polymers based on fructose from Agave tequilana Weber var. azul, known as fructans, have a great potential as carriers of drugs due to their chemical structure, which makes them non degradable in the upper digestive tract, but enzymatically degradable in the colon. However, esterification is necessary to obtain hydrophobic compounds capable to preserve drugs at stomach conditions. We esterified fructans with acetyl, lauroyl and palmitoyl moieties for encapsulating ibuprofen as a model drug. Esterification of fructan was confirmed using attenuated total reflectance infrared spectroscopy (ATR-FTIR), while the degree of substitution (DS) was quantified by proton nuclear magnetic resonance (¹H-NMR).

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Carmen Miramontes-Corona, Marco A. Escalante, Ezequiel Delgado, Rosa I. Corona-González, Humberto Vázquez-Torres, and Guillermo Toriz "Characterization of modified agave fructans used as drug carriers to the colon by spectroscopy techniques", Proc. SPIE 11128, Infrared Remote Sensing and Instrumentation XXVII, 111280X (9 September 2019); https://doi.org/10.1117/12.2526135

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