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5 March 2021 In vivo single cell tracking of progenitor cells labeled with nanowire lasers using optical coherence tomography and fluorescence microscopy dual-modality imaging
Xuzhou Li, Wei Zhang, Yanxiu Li, Xiaoqin Wu, Yannis M. Paulus M.D., Xueding Wang, Xudong Fan, Mingyang Wang, Xiaotian Tan
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Proceedings Volume 11634, Multimodal Biomedical Imaging XVI; 1163406 (2021) https://doi.org/10.1117/12.2576467
Event: SPIE BiOS, 2021, Online Only
Abstract
We demonstrate that the lasing emission spectra of nanowire lasers internalized by progenitor retinal pigmented epithelial cells (RPE) can be exploited as unique “identifiers” to label each individual cell during long-time in vivo observation. Since nanowires could provide a 25 dB signal enhancement in optical coherence tomography (OCT) and green emission in fluorescence microscopy (FM), we utilized OCT and FM concurrently to track the 3D trajectories of RPE cells in rabbit retina in vivo migrating towards the laser-induced wounds. Our study confirms the feasibility of nanowire lasers as novel probes in single progenitor cell tracking, which could potentially facilitate the fundamental research in regenerative medicine.
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Xuzhou Li, Wei Zhang, Yanxiu Li, Xiaoqin Wu, Yannis M. Paulus M.D., Xueding Wang, Xudong Fan, Mingyang Wang, and Xiaotian Tan "In vivo single cell tracking of progenitor cells labeled with nanowire lasers using optical coherence tomography and fluorescence microscopy dual-modality imaging", Proc. SPIE 11634, Multimodal Biomedical Imaging XVI, 1163406 (5 March 2021); https://doi.org/10.1117/12.2576467
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KEYWORDS
In vivo imaging
Nanowires
Optical coherence tomography
Luminescence
Microscopy
Optical tracking
Laser optics
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