Towards peripheral neuron regeneration: imaging nerve biomechanics using Brillouin spectroscopy

Vsevolod Cheburkanov; Junwei Du; Mikhail Berezin; Vladislav V. Yakovlev

doi:10.1117/12.2650957

6 March 2023 Towards peripheral neuron regeneration: imaging nerve biomechanics using Brillouin spectroscopy

Vsevolod Cheburkanov, Junwei Du, Mikhail Berezin, Vladislav V. Yakovlev

Proceedings Volume 12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; 123730E (2023) https://doi.org/10.1117/12.2650957
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Poor recovery of peripheral neuron damage caused by trauma is currently among the most common causes for low quality of life among US population. Disabilities caused by neuron damage and poor recovery tend to cause early workforce retirement, creating a gap in skilled workforce in the US. Recent studies suggest that biomechanical vectors play an important role in nerve recovery and functionality restoration. This preliminary study focuses on investigating of correlation between biomechanical properties of murine sciatic nerve and Brillouin elasticity data. Combined Brillouin-Raman spectroscopy was used as a label-free method of elasticity measurement.

Citation Download Citation

Vsevolod Cheburkanov, Junwei Du, Mikhail Berezin, and Vladislav V. Yakovlev "Towards peripheral neuron regeneration: imaging nerve biomechanics using Brillouin spectroscopy", Proc. SPIE 12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 123730E (6 March 2023); https://doi.org/10.1117/12.2650957

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