Tissue optical clearing for fNIRS studies in radiotherapy

Ekaterina N. Lazareva; Priya Karthikeyan; Jesse Lohela; Kalle Inget; Vesa Korhonen; Sakari Karhula; Juha Nikkinen; Valery Tuchin; Teemu Myllyla

doi:10.1117/12.2687657

27 November 2023 Tissue optical clearing for fNIRS studies in radiotherapy

Ekaterina N. Lazareva, Priya Karthikeyan, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, Valery Tuchin, Teemu Myllyla

Author Affiliations +

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 1277014 (2023) https://doi.org/10.1117/12.2687657
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Abstract

Functional near infrared spectroscopy (fNIRS) is a non-invasive and safe method to measure hemodynamics of the cerebral cortex. The use fNIRS in combination with brain radiotherapy is currently of our high interest since it provides a method to measure tissue oxygenation levels during irradiation. This can potentially help to advance the field of personalized cancer treatment. However, one limitation of the fNIRS technique is associated with penetration depth into tissues. Tissue optical clearing (TOC) could potentially improve the efficiency of fNIRS and for this use of radiopaque solutions, such as Omnipaque™ (iohexol), Visipaque™ (iodixanol), etc., are proposed as effective optical clearing agents (OCA). The presented study experiments the feasibility of using TOC for fNIRS measurements in radiotherapy. The effectiveness of isosmotic Visipaque™ and an OCA with a high osmolarity, a solution of 70% glycerol with 10% DMSO, was evaluated when using chicken samples.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Ekaterina N. Lazareva, Priya Karthikeyan, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, Valery Tuchin, and Teemu Myllyla "Tissue optical clearing for fNIRS studies in radiotherapy", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 1277014 (27 November 2023); https://doi.org/10.1117/12.2687657

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