Multichannel quantification of biomedical magnetic resonance spectroscopic signals

Leen Vanhamme; Sabine Van Huffel

doi:10.1117/12.325684

2 October 1998 Multichannel quantification of biomedical magnetic resonance spectroscopic signals

Leen Vanhamme, Sabine Van Huffel

Proceedings Volume 3461, Advanced Signal Processing Algorithms, Architectures, and Implementations VIII; (1998) https://doi.org/10.1117/12.325684
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1998, San Diego, CA, United States

Abstract

Quantification of individual magnetic resonance spectroscopy (MRS) signals modeled as a sum of exponentially damped sinusoids, is possible using interactive nonlinear least-squares fitting methods which provide maximum likelihood parameter estimates or using fully automatic, but statistically suboptical black-box methods. In kinetic experiments consecutive time series of MRS spectra are measured in which some of the parameters are known to remain constant over time. The purpose of this paper is to show how the previously mentioned methods can be extended to the simultaneous processing of all spectra in the time series using this additional information between the spectra. We will show that this approach yields statistically better results than processing the different signals separately.

Citation Download Citation

Leen Vanhamme and Sabine Van Huffel "Multichannel quantification of biomedical magnetic resonance spectroscopic signals", Proc. SPIE 3461, Advanced Signal Processing Algorithms, Architectures, and Implementations VIII, (2 October 1998); https://doi.org/10.1117/12.325684

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