Refractive index matching of tissue components as a new technology for correlation and diffusing-photon spectroscopy and imaging

Valery V. Tuchin; Joseph P. Culver; Cecil Cheung; Svetlana A. Tatarkova; Michael A. DellaVecchia M.D.; Dmitry A. Zimnyakov; Anatoly A. Chaussky; Arjun G. Yodh; Britton Chance

doi:10.1117/12.347479

30 April 1999 Refractive index matching of tissue components as a new technology for correlation and diffusing-photon spectroscopy and imaging

Valery V. Tuchin, Joseph P. Culver, Cecil Cheung, Svetlana A. Tatarkova, Michael A. DellaVecchia M.D., Dmitry A. Zimnyakov, Anatoly A. Chaussky, Arjun G. Yodh, Britton Chance

Author Affiliations +

Proceedings Volume 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III; (1999) https://doi.org/10.1117/12.347479
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The refractive index matching of components of highly scattering tissue has a strong influence on its transmittance and reflectance what can be considered as a new tool for imaging within relatively thick tissues. We present experimental data on various solutions, gels and oils influence on optical properties of in vivo human eye and in vivo human skin. The dynamics of tissue optical properties depending on matter diffusion rate within tissue is studied. The possible application of refractive index matching effect for diffusing-photon imaging is discussed.

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Valery V. Tuchin, Joseph P. Culver, Cecil Cheung, Svetlana A. Tatarkova, Michael A. DellaVecchia M.D., Dmitry A. Zimnyakov, Anatoly A. Chaussky, Arjun G. Yodh, and Britton Chance "Refractive index matching of tissue components as a new technology for correlation and diffusing-photon spectroscopy and imaging", Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); https://doi.org/10.1117/12.347479

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