Raman chemical imaging using flexible fiberscope technology

Ryan D. Smith; Matthew P. Nelson; Patrick J. Treado

doi:10.1117/12.379593

14 March 2000 Raman chemical imaging using flexible fiberscope technology

Ryan D. Smith, Matthew P. Nelson, Patrick J. Treado

Proceedings Volume 3920, Spectral Imaging: Instrumentation, Applications, and Analysis; (2000) https://doi.org/10.1117/12.379593
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Raman chemical imaging microscopy has been proven to be a powerful methodology for analyzing a wide range of solid state materials. For biomedical applications, Raman chemical imaging has been shown to be effective in assessing clinical samples including breast tissue lesions and arterial plaques. With Raman chemical imaging systems based on microscopes, materials can be analyzed with molecular specificity, without labor intensive sample preparation or the use of dyes and stains at diffraction limited spatial resolution (< 250 nm). However, microscopes cannot readily be used to perform in vivo measurements. With the recent development of flexible fiberscope technology, Raman chemical imaging can be applied within remote and confined environments and the potential exists for in vivo use. This manuscript provides the first description of novel Raman chemical imaging fiberscope technology, including data analysis strategies for extracting information from Raman chemical imaging data sets.

Citation Download Citation

Ryan D. Smith, Matthew P. Nelson, and Patrick J. Treado "Raman chemical imaging using flexible fiberscope technology", Proc. SPIE 3920, Spectral Imaging: Instrumentation, Applications, and Analysis, (14 March 2000); https://doi.org/10.1117/12.379593

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