Blood immersion and sedimentation study using OCT technique

Valery V. Tuchin; Xiangqun Xu; Ruikang K. Wang

doi:10.1117/12.446639

25 October 2001 Blood immersion and sedimentation study using OCT technique

Valery V. Tuchin, Xiangqun Xu, Ruikang K. Wang

Proceedings Volume 4597, Biophotonics Instrumentation and Analysis; (2001) https://doi.org/10.1117/12.446639
Event: International Symposium on Photonics and Applications, 2001, Singapore, Singapore

Abstract

The refractive index matching (immersion) method is used to enhance the optical penetration depth of whole blood in in vitro study by the NIR optical coherence tomography (OCT) technique. It was found that for tested agents (glucose, dextrans, propylene glycol, and trazograph) the enhancement of penetration was from 20 % to 150 %. In the blood sedimentation study, regular or irregular oscillations or jumps of the RBC/plasma boundary were observed. The one-minute time period of regular oscillations correlated well with the kinetics of the aggregation process. For the first time OCT images of blood aggregates in a small plastic vessel were observed. Presented results have potentials in intra-vascular OCT imaging and in blood sedimentation and aggregation studies for diagnostic purposes.

Citation Download Citation

Valery V. Tuchin, Xiangqun Xu, and Ruikang K. Wang "Blood immersion and sedimentation study using OCT technique", Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); https://doi.org/10.1117/12.446639

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