Optical clearing of blood by dextrans

Xiangqun Xu; Liu Wu; Ruikang K. Wang; James B. Elder; Valery V. Tuchin

doi:10.1117/12.518630

22 September 2003 Optical clearing of blood by dextrans

Xiangqun Xu, Liu Wu, Ruikang K. Wang, James B. Elder, Valery V. Tuchin

Proceedings Volume 5149, Laser Applications in Medicine, Biology, and Environmental Science; (2003) https://doi.org/10.1117/12.518630
Event: International Conference on Lasers, Applications, and Technologies 2002, 2002, Moscow, Russian Federation

Abstract

Effect of dextrans on optical property of blood in stasis and in flow was investigated with optical coherence tomography. The mechanisms for blood optical clearing are the characteristics of the types of dextrans employed and their concentrations. Among the substances applied, Dx500 at 0.5 gdl^-1 and 5 gdl^-1 are most effective in improving light penetration depth through the blood in stasis and in flow respectively. Optical clearing of blood was achieved by refractive index matching and aggregation of erythrocytes induced by dextrans.

Citation Download Citation

Xiangqun Xu, Liu Wu, Ruikang K. Wang, James B. Elder, and Valery V. Tuchin "Optical clearing of blood by dextrans", Proc. SPIE 5149, Laser Applications in Medicine, Biology, and Environmental Science, (22 September 2003); https://doi.org/10.1117/12.518630

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