SPECT study of low intensity He-Ne laser intravascular irradiation therapy for brain infarction

Xue-Chang Xiao; Jia-Zheng Dong; Xiao-Fan Chu; Shao-Wei Jia; Timon Cheng-Yi Liu; Jian-Ling Jiao; Xi-Yuan Zheng; Ci-Xiong Zhou

doi:10.1117/12.546102

8 December 2003 SPECT study of low intensity He-Ne laser intravascular irradiation therapy for brain infarction

Xue-Chang Xiao, Jia-Zheng Dong, Xiao-Fan Chu, Shao-Wei Jia, Timon Cheng-Yi Liu, Jian-Ling Jiao, Xi-Yuan Zheng, Ci-Xiong Zhou

Author Affiliations +

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546102
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

We used single photon emission computed tomography (SPECT) in brain perfusion imaging to study the changes of regional cerebral blood flow (rCBF) and cerebral function in brain infarction patients treated with intravascular laser irradiation of blood (ILIB). 17 of 35 patients with brain infarction were admitted to be treated by ILIB on the base of standard drug therapy, and SPECT brain perfusion imaging was performed before and after ILIB therapy with self-comparison. The results were analyzed in quantity with brain blood flow function change rate (BFCR%) model. Effect of ILIB during the therapy process in the other 18 patients were also observed. In the 18 patients, SPECT indicated an improvement of rCBF (both in focus and in total brain) and cerebral function after a 30 min-ILIB therapy. And the 17 patients showed an enhancement of total brain rCBF and cerebral function after ILIB therapy in comparison with that before, especially for the focus side of the brain. The enhancement for focus itself was extremely obvious with a higher significant difference (P<0.0001). The mirror regions had no significant change (P>0.05). BFCR% of foci was prominently higher than that of mirror regions (P<0.0001). In conclusion, the ILIB therapy can improve rCBF and cerebral function and activate brain cells of patients with brain infarction. The results denote new evidence of ILIB therapy for those patients with cerebral ischemia.

Citation Download Citation

Xue-Chang Xiao, Jia-Zheng Dong, Xiao-Fan Chu, Shao-Wei Jia, Timon Cheng-Yi Liu, Jian-Ling Jiao, Xi-Yuan Zheng, and Ci-Xiong Zhou "SPECT study of low intensity He-Ne laser intravascular irradiation therapy for brain infarction", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546102

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KEYWORDS

Brain

Single photon emission computed tomography

Neuroimaging

Blood

Low-intensity laser therapy

Mirrors

Helium neon lasers

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