Up-converting phosphor technology-based biosensor

Kun Yu; Lei Zhou; Lei Liu; Lihua Huang; Zhongqiang Yan; Yongkai Zhao; Ruifu Yang; Huijie Huang

doi:10.1117/12.741620

1 May 2007 Up-converting phosphor technology-based biosensor

Kun Yu, Lei Zhou, Lei Liu, Lihua Huang, Zhongqiang Yan, Yongkai Zhao, Ruifu Yang, Huijie Huang

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 653422 (2007) https://doi.org/10.1117/12.741620
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

A new generation of Up-converting phosphor technology-based biosensors (UPT-based biosensor) has been developed for immunoassay, where a kind of novel Up-converting phosphor (UCP) particle serves as the biological marker. Its control system is based on a micro-computer control unit instead of a personal computer, which results in low power consumption, high reliability and portability for field detection. By detecting the content of the UCP on the test strip, the system figures out the concentration of the biological molecular of interest, which can be used in field examination of biological analytes. In this paper, a series concentration of standard samples have been tested by the biosensor, which is proved to have higher sensitivity (~ng/ml), higher stability (CV<3~5%), better linear relationship and an excellent correlation (R²≥0.95). The UPT-based biosensor has stable, reliable and sensitive performances. It can meet the need of various rapid bioassay applications.

Citation Download Citation

Kun Yu, Lei Zhou, Lei Liu, Lihua Huang, Zhongqiang Yan, Yongkai Zhao, Ruifu Yang, and Huijie Huang "Up-converting phosphor technology-based biosensor", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653422 (1 May 2007); https://doi.org/10.1117/12.741620

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