Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes

Xinmai Yang; Sara Skrabalak; Erich Stein; Bin Wu; Xunbin Wei; Younan Xia; Lihong V. Wang

doi:10.1117/12.762401

28 February 2008 Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes

Xinmai Yang, Sara Skrabalak, Erich Stein, Bin Wu, Xunbin Wei, Younan Xia, Lihong V. Wang

Author Affiliations +

Proceedings Volume 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 68560I (2008) https://doi.org/10.1117/12.762401
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages, with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross-sections, should be better suited for in vivo applications. In this study, we tested Au nanocages as a contrast agent for PAT. The result suggests that Au nanocages are promising contrast agents for our applications. We also present PAT results when novel, dye-containing nanoparticles are used as contrast agents.

Citation Download Citation

Xinmai Yang, Sara Skrabalak, Erich Stein, Bin Wu, Xunbin Wei, Younan Xia, and Lihong V. Wang "Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560I (28 February 2008); https://doi.org/10.1117/12.762401

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