Cellular model studies of brain-mediated phototherapy on Alzheimer's disease

Ling Zhu; Timon Cheng-Yi Liu; Bina Hu; Xiao-Yun Li; Yong-Qing Wang

doi:10.1117/12.823335

6 March 2009 Cellular model studies of brain-mediated phototherapy on Alzheimer's disease

Ling Zhu, Timon Cheng-Yi Liu, Bina Hu, Xiao-Yun Li, Yong-Qing Wang

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72801E (2009) https://doi.org/10.1117/12.823335
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

Alzheimer's disease (AD) is now the most common neurodegenerative disease. Despite approval of several drugs for AD, the disease continues to rob millions of their memories and their lives. We have studied the cellular models of brain-mediated phototherapy on AD, and the studies will be reviewed in this paper. Genetic studies have shown that dysfunction of amyloid β-protein (Aβ) or tau is sufficient to cause AD. Aβ or Aβ induced redox stress induced neuron apoptosis might be as a cellular model of AD. We found red light at 640±15 nm from light emitting diode array (RLED640) might inhibit Aβ 25-35 induced PC12 cell apoptosis, which is mediated by cyclic adenosine monophosphate, and it might inhibit hydrogen peroxide (H₂O₂) induced differentiated PC12 cell (dPC12) apoptosis, which is mediated by tyrosine hydroxylase. There is rhythm dysfunction in AD. We found low intensity 810 nm laser irradiation might rehabilitate TNF-alpha induced inhibition of clock gen expression of NIH 3T3 fibroblasts. Our studies provide a foundation for photobiomodulation on brain to rehabilitate AD.

Citation Download Citation

Ling Zhu, Timon Cheng-Yi Liu, Bina Hu, Xiao-Yun Li, and Yong-Qing Wang "Cellular model studies of brain-mediated phototherapy on Alzheimer's disease", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72801E (6 March 2009); https://doi.org/10.1117/12.823335

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