Developing a miniaturized continuous flow electrochemical cell for biosensor applications

M. Ilie; E. Ovreiu; R. Dejana; V. Foglietti; L. Nardi; A. Masci; B. Lanza; L. Della Seta; M-R. Montereali; W. Vastarella; R. Pilloton

doi:10.1117/12.823688

7 January 2009 Developing a miniaturized continuous flow electrochemical cell for biosensor applications

M. Ilie, E. Ovreiu, R. Dejana, V. Foglietti, L. Nardi, A. Masci, B. Lanza, L. Della Seta, M-R. Montereali, W. Vastarella, R. Pilloton

Author Affiliations +

Proceedings Volume 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV; 729724 (2009) https://doi.org/10.1117/12.823688
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 2008, Constanta, Romania

Abstract

The development of a miniaturized electrochemical cell for biosensor application regards both the structuring of an array of electrodes in a fluidic chamber and their connections to the control & processing unit The sensitivity of the chrono-amperometric measurement performed with the cell is increased by: (a) integrating the reference electrode on the same chip with the counter- and working- electrodes, (b) designing a specific pattern of the gold electrodes and (c) serially distributing them along the pipeline reservoir. Borosilicate glass is used as substrate for the electrodes, allowing, due to its transparency, an accurate and easy pad to pad alignment of the up-side-down chip versus a PCB soldered on a standard DIL 40 socket. This alignment is necessary to accomplish the elastomer-based-solderless electric contact, between chip and PCB. The solderless contact significantly improves both reliability and signal processing accuracy. The reservoir and its cover are micromachined out of silicone rubber respectively photosensitive glass in order to easy disassemble the fluidic chamber without any damage. Both thickness and elasticity of the photosensitive glass rend the device less brittle. A plug-in -plug-flow device with improved characteristics has been obtained with a modular structure that allows further extension of the number of electrodes.

Citation Download Citation

M. Ilie, E. Ovreiu, R. Dejana, V. Foglietti, L. Nardi, A. Masci, B. Lanza, L. Della Seta, M-R. Montereali, W. Vastarella, and R. Pilloton "Developing a miniaturized continuous flow electrochemical cell for biosensor applications", Proc. SPIE 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 729724 (7 January 2009); https://doi.org/10.1117/12.823688

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available